Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Elizabeth J AdolphLillian B Nanney

Abstract

The filling of wound cavities with new tissue is a challenge. We previously reported on the physical properties and wound healing kinetics of prefabricated, gas-blown polyurethane (PUR) scaffolds in rat and porcine excisional wounds. To address the capability of this material to fill complex wound cavities, this study examined the in vitro and in vivo reparative characteristics of injected PUR scaffolds employing a sucrose porogen. Using the porcine excisional wound model, we compared reparative outcomes to both preformed and injected scaffolds as well as untreated wounds at 9, 13, and 30 days after scaffold placement. Both injected and preformed scaffolds delayed wound contraction by 19% at 9 days and 12% at 13 days compared to nontreated wounds. This stenting effect proved transient since both formulations degraded by day 30. Both types of scaffolds significantly inhibited the undesirable alignment of collagen and fibroblasts through day 13. Injected scaffolds were highly compatible with sentinel cellular events of normal wound repair cell proliferation, apoptosis, and blood vessel density. The present study provides further evidence that either injected or preformed PUR scaffolds facilitate wound healing, support tissue infi...Continue Reading

References

May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T P SullivanP Mertz
Jan 10, 2002·Otolaryngologic Clinics of North America·Jacqueline T ChengMark M Hamilton
May 12, 2005·Journal of Vascular Surgery·Eliot N MostowUNKNOWN OASIS Venus Ulcer Study Group
Jun 21, 2006·Dermatologic Therapy·Leslie BaumannSogol Saghari
Jun 28, 2006·Journal of Microencapsulation·Sha HuangYan Jin
Nov 25, 2006·The Journal of Investigative Dermatology·Martina I OkwuezeLillian B Nanney
Apr 17, 2007·The Journal of Investigative Dermatology·Richard A F ClarkMarcia G Tonnesen
May 18, 2007·Advanced Drug Delivery Reviews·James D KretlowAntonios G Mikos
Sep 18, 2007·Medical Engineering & Physics·C Pailler-MatteiH Zahouani
Oct 19, 2007·Toxicologic Pathology·Liora Braiman-WiksmanTamar Tennenbaum
Oct 30, 2007·Journal of Pharmaceutical Sciences·Joshua S BoatengGillian M Eccleston
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Yusuf KhanCato T Laurencin
Aug 30, 2008·The American Journal of Pathology·Lillian B NanneyLeslie I Gold
May 30, 2009·Stroke; a Journal of Cerebral Circulation·Edouard FonckNikolaos Stergiopulos
Nov 12, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K SenMichael T Longaker
Apr 13, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bing LiScott A Guelcher
Oct 18, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·John Edward Greenwood, Bronwyn Louise Dearman
Nov 9, 2011·Biomaterials·Christopher E NelsonCraig L Duvall
Nov 15, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·John Edward Greenwood, Bronwyn Louise Dearman
Nov 23, 2011·Journal of Biomedical Materials Research. Part a·Elizabeth J AdolphScott A Guelcher
Dec 18, 2013·Advanced Materials·Christopher E NelsonCraig L Duvall
Feb 15, 2014·Advances in Wound Care·Susan W VolkArdeshir Bayat
Feb 15, 2014·Advances in Wound Care·Ge ZhaoJohn E Olerud
Oct 8, 2014·Journal of Biomaterials Science. Polymer Edition·Elizabeth J AdolphLillian B Nanney
Jan 17, 2015·Biomaterials·Elizabeth R LordenHoward Levinson

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Citations

Oct 8, 2016·Advanced Healthcare Materials·John R MartinCraig L Duvall
May 23, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheeny Lan LevengoodMiqin Zhang
Aug 2, 2017·Tissue Engineering. Part C, Methods·Prarthana PatilCraig L Duvall
Dec 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shan-Hui HsuCheng-Wei Chen
Oct 27, 2020·Bioactive Materials·Sophie Wendels, Luc Avérous
Feb 7, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Qingxia ZhuJianjun Guan

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