Abstract
To demonstrate that injecting drug use is a major risk factor of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection and injecting drug users may be a reservoir of CA-MRSA infection in our community, we conducted a matched case-control study. Cases were CA-MRSA-infected patients at University of California, Davis, Medical Center, Sacramento, CA, from December 1, 2003, to May 31, 2004. Two control groups were community-associated methicillin-susceptible S. aureus (CA-MSSA)-infected patients and a randomly selected uninfected patient group in the same hospital. Controls were matched to cases by age and isolate culture date. One hundred twenty-seven CA-MSSA patients and 381 randomly selected uninfected controls were selected to match the 127 CA-MRSA cases. The adjusted odds ratio of injecting drug use compared with the CA-MSSA group was 2.11 (95% confidence interval [CI], 1.1-4.3) and 4.09 (95% CI, 2.2-7.5) compared with the uninfected group. We suggest that injecting drug use is a significant risk factor for CA-MRSA infection, which could contribute to the increasing prevalence of CA-MRSA in an urban community.
References
Jan 1, 1992·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierY Piémont
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P H SummanenS M Finegold
Feb 1, 1997·American Journal of Public Health·M J RobertsonA Westerfelt
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I A BinswangerB R Edlin
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E L MurphyB R Edlin
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bianca QuagliarelloFranklin D Lowy
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philippe DufourHervé Richet
Nov 7, 2002·Archives of Surgery·Hobart W Harris, David M Young
Jun 28, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Henry C BaggettJay C Butler
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George K SiberryJames Dick
Apr 3, 2004·Pediatrics·Dinusha W DietrichLeonard A Mermel
Jun 10, 2004·Infection·S Bassetti, M Battegay
Jul 8, 2005·Journal of Clinical Microbiology·Yoko TakizawaTatsuo Yamamoto
Nov 4, 2005·The New England Journal of Medicine·Rachel J Gordon, Franklin D Lowy
Jul 11, 2006·Journal of Clinical Microbiology·Hsin HuangStuart H Cohen
Aug 18, 2006·The New England Journal of Medicine·Gregory J MoranUNKNOWN EMERGEncy ID Net Study Group
Citations
Dec 17, 2008·Journal of General Internal Medicine·Joanna L StarrelsJoshua P Metlay
Mar 6, 2010·Epidemiology and Infection·E Lloyd-SmithM G Romney
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Olivier ClercLaurence Senn
Jul 9, 2010·Clinical Microbiology Reviews·Michael Z David, Robert S Daum
Jul 17, 2010·American Journal of Public Health·Dawn M SievertMatthew L Boulton
Mar 1, 2012·The Journal of Infection·Yiu-hong LeungThomas Ho-fai Tsang
Mar 11, 2011·Journal of Medical Microbiology·Karishma S KaushikA K Praharaj
Feb 18, 2015·American Journal of Infection Control·Jason E FarleyKaren Carroll
Oct 17, 2012·The Journal of Infection·Michael MarksJustin F Doherty
Apr 3, 2010·British Medical Bulletin·Fiona J Cooke, Nicholas M Brown
Mar 29, 2012·The American Journal of Bioethics : AJOB·Janet Malek, Judith Daar
May 31, 2019·Infectious Diseases·Marit Nymoen AasbrennDag Berild
Sep 23, 2018·Infectious Diseases and Therapy·Gregory J MoranPhilippe Prokocimer
Aug 3, 2017·Open Forum Infectious Diseases·Betsy SzetoElaine L Larson
Oct 1, 2008·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Carrie W Nemerovski, Kristin C Klein
Dec 3, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maíris Alarcão Duarte de Oliveira SilvestreCarlos Magno Castelo Branco Fortaleza
Jan 14, 2021·The Journal of Applied Laboratory Medicine·Christopher W FarnsworthSophonie Jean
Mar 26, 2010·The Lancet Infectious Diseases·Jonathan A Otter, Gary L French