Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis

Stem Cells International
José M LassoMaría Eugenia Fernández-Santos

Abstract

Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap. This is the first phase I-IIA clinical trial (phase I/IIA clinical trial, unicentric, randomized, controlled, and two parallel groups), to evaluate the safety of a new therapy with ADRC-enriched fat grafting (ADRC: group I) for laryngoplasty after unilateral vocal fold paralysis. Control group patients received centrifuged autologous fat (CAF: group II) grafts. Overall mean age is 52.49 ± 16.60 years. Group I (ADRC): 7 patients (3 males and 4 females), 52.28 ± 20.95 year. Group II (CAF): 7 patients (3 males and 4 females), 52.71 ± 12.59 year. VHI-10 test showed that preoperative mean score was 24.21 ± 8.28. Postoperative mean score was 6.71...Continue Reading

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Citations

Apr 8, 2020·BMC Musculoskeletal Disorders·Masanori TsubosakaRyosuke Kuroda
Oct 25, 2020·Stem Cell Research & Therapy·Angelo TrivisonnoGabriele Toietta
Apr 1, 2021·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Wen-Hsuan TsengTsung-Lin Yang
Aug 11, 2021·The Laryngoscope·Alex S LukeGregory R Dion
Jan 19, 2021·ACS Biomaterials Science & Engineering·Camilo Mora-NavarroDonald O Freytes

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Methods Mentioned

BETA
sedation
flow cytometry

Software Mentioned

BioMet®Phon

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