PMID: 6535644Dec 1, 1984Paper

Injection of murine embryonal carcinoma cells and embryo-derived pluripotential cells into mouse blastocysts

Cell Differentiation
K BeckerJ Schöneich

Abstract

Two pluripotential mouse cell lines, the OTT 6050-derived cell line TCE and the embryo-derived stem cell line BLC-1, were injected into blastocysts to analyze their developmental potential. The contribution of TCE cells to the embryo was found to be limited and sporadic. There was no indication of a preferential colonization of extraembryonal membranes or developmentally related tissues in adult chimeras. BLC-1 cells failed to colonize the embryo. This indicates that a normal karyotype, pluripotency, and cell surface markers which are shared by cells of early embryos are not necessarily sufficient markers for their ability to participate in embryogenesis.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M J DeweyB Mintz
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Mintz, K Illmensee
Nov 6, 1975·Nature·V E PapaioannouM J Evans
Sep 1, 1974·Genetics·D G Whittingham
Oct 1, 1974·The Journal of Experimental Medicine·R L Brinster
Aug 15, 1980·Science·G R Martin
Dec 1, 1984·Cell Differentiation·V E PapaioannouJ Rossant
May 1, 1984·Experimental Cell Research·A M WobusJ Schöneich
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T A Stewart, B Mintz
Jun 1, 1981·Genetical Research·A McLaren, M Buehr

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Citations

Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew A WyczalkowskiLarry A Taber

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