Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

Journal of Controlled Release : Official Journal of the Controlled Release Society
Tatsuhiro IshidaHiroshi Kiwada

Abstract

Steric stabilization of the surface of liposomes by a PEG conjugated lipid results in reduced recognition of the liposomes by the cells of the mononuclear phagocyte system and consequently extended their circulation times (t(1/2) approximately 20h in rat). Recently, we reported on the "accelerated blood clearance phenomenon", causing "invisible" PEGylated liposomes to be cleared very rapidly from the circulation upon repeated injection. In addition, we reported that certain serum factor(s) secreted into the blood after the first dose of PEGylated liposomes play an essential role in the phenomenon. The aim of the present study was to identify the major serum protein(s) responsible for the phenomenon and to unravel their mode of action. The amount of protein binding to PEGylated liposomes during incubation with serum hardly correlated with the extent of the phenomenon. PEGylated liposomes incubated with serum obtained from rats pre-injected 5 days before with the same liposomes showed a much more complex pattern of bound proteins than when incubated with naïve serum, as revealed by 2D-PAGE and SDS-PAGE. Subsequent analysis with LC-MS/MS and Western blot showed that the major pre-treated serum protein binding to PEGylated liposome...Continue Reading

References

Nov 18, 1991·Biochimica Et Biophysica Acta·D D LasicD Papahadjopoulos
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Jan 1, 1986·Annual Review of Medicine·J F Bohnsack, E J Brown
Oct 12, 1994·Biochimica Et Biophysica Acta·V P TorchilinC A Gentry
Jun 1, 1993·Journal of Pharmacokinetics and Biopharmaceutics·H HarashimaH Kiwada
Jun 6, 2000·Advanced Drug Delivery Reviews·J A Kamps, G L Scherphof
Oct 19, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T SafraA Gabizon
Mar 23, 2001·Nature Immunology·A ShibuyaH Nakauchi
Jan 5, 2002·Current Drug Metabolism·T IshidaH Kiwada
Jan 16, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·P LavermanG Storm
Nov 14, 2002·Bioscience Reports·Tatsuhiro IshidaHiroshi Kiwada
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Apr 4, 2003·International Journal of Pharmaceutics·Tatsuhiro IshidaHiroshi Kiwada
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xin Yu WangHiroshi Kiwada
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada

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Citations

Feb 26, 2013·Journal of Neurology·Hirotaka TanakaHideaki Hara
Jul 28, 2009·Pharmaceutical Research·Tsutomu IshiharaTohru Mizushima
Jun 16, 2010·Pharmaceutical Research·Jeremy D Heidel, Mark E Davis
May 16, 2013·Pharmaceutical Research·Eman AlaaeldinHiroshi Kiwada
Jun 13, 2013·Pharmaceutical Research·Arehalli S ManjappaRayasa S Ramachandra Murthy
Oct 17, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chunling WangYihui Deng
Mar 19, 2013·International Journal of Pharmaceutics·Kacoli Sen, Mahitosh Mandal
May 10, 2012·Accounts of Chemical Research·Lígia C Gomes-da-SilvaJoão N Moreira
Mar 6, 2012·Chemical Society Reviews·Nazila KamalyOmid C Farokhzad
Dec 13, 2006·Anti-cancer Drugs·Frederike K EngelsJaap Verweij
Dec 18, 2009·Endocrinology·Banu S ZolnikMarina A Dobrovolskaia
Mar 30, 2012·International Journal of Nanomedicine·Mohamad AlamehAbderrazzak Merzouki
Aug 14, 2012·International Journal of Nanomedicine·Kazuo WatanabeYoshie Maitani
Jun 23, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Chun ZhangFei Liao
Nov 14, 2013·Cellular and Molecular Life Sciences : CMLS·Lígia Catarina Gomes-da-SilvaJoão Nuno Moreira
Mar 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeremy D HeidelMark E Davis
Jan 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrei MaksimenkoPatrick Couvreur
Sep 10, 2013·Biotechnology Advances·Zhiyong WangXiaoyuan Chen
Jul 23, 2013·Advanced Drug Delivery Reviews·Michael D BuschmannVincent Darras
Feb 28, 2009·Pharmaceutical Research·Wim JiskootHuub Schellekens
Jul 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jantana YahuafaiNaoto Oku
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Mar 7, 2013·Molecular Pharmaceutics·Eun Jung ChoYoon Yeo
Jun 17, 2014·Drug Delivery and Translational Research·Johan J F Verhoef, Thomas J Anchordoquy
Feb 16, 2010·Expert Opinion on Drug Delivery·Helen O McCarthyArash Hatefi
Mar 25, 2011·Drug Metabolism Reviews·Kazuaki TaguchiMasaki Otagiri
Feb 6, 2008·Expert Opinion on Drug Delivery·Giovanni TosiMaria Angela Vandelli
Jun 9, 2007·Expert Opinion on Biological Therapy·Garrett R Rettig, Kevin G Rice
Dec 2, 2010·Expert Opinion on Drug Delivery·Awa DickoPaul G Tardi
Dec 4, 2013·Expert Opinion on Drug Delivery·Driton VllasaliuSnow Stolnik
Jul 2, 2008·Expert Opinion on Drug Delivery·Eder L Romero, Maria Jose Morilla
Jun 11, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shigeru Kawakami, Mitsuru Hashida
Jun 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Burcin OzbakirTwan Lammers
Mar 21, 2008·Journal of Pharmaceutical Sciences·Daryl C DrummondDmitri B Kirpotin

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