Injection site effects on the pharmacokinetics and glucodynamics of insulin lispro and regular insulin

Diabetes Care
E W ter BraakD Kurtz

Abstract

The pharmacokinetics and glucodynamics of a new insulin analog, insulin lispro, and regular human insulin were compared and contrasted after subcutaneous administrations in femoral, deltoid, and abdominal injection sites. Single 0.2 U/kg doses of insulin lispro and regular insulin were administered to 12 healthy subjects in a six-way randomized crossover fashion. Each dose was given after an overnight fast in one of three injection sites: abdominal, deltoid, or femoral. Study drugs were given during a manual euglycemic glucose clamp. Blood samples were collected over the 12-h clamp for measurement of insulin-reactive components, with pharmacokinetic and glucodynamic measurements derived from these serum insulin and clamp measurements. Glucodynamic comparisons between insulin lispro and regular insulin showed a greater maximum infusion rate (Rmax) at an earlier time (TRmax), regardless of injection site. The total glucose infused (Gtot) showed nearly identical values between sites for insulin lispro. Regular insulin showed greater Gtot values from deltoid and femoral injections. When comparisons were made between drugs, regular insulin produced significantly greater Gtot, primarily driven by the increased Gtot from deltoid and f...Continue Reading

Citations

Jan 10, 2013·Clinical Pharmacokinetics·Miroslav DostalekManoranjenni Chetty
Oct 4, 2002·The American Journal of Medicine·John E Gerich
Jun 6, 2000·Advanced Drug Delivery Reviews·J Brange, A Vølund
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·M R Burge, D S Schade
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·M R BurgeD S Schade
Jan 5, 2006·Diabetes & Metabolism·B Guerci, J P Sauvanet
Oct 12, 2010·Diabetes & Metabolism·A FridUNKNOWN Scientific Advisory Board for the Third Injection Technique Workshop
Apr 30, 1999·Allergy·M Lluch-BernalJ Sastre
Apr 29, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·N Kong, R E Ryder
Sep 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·Z MilicevicZ Metelko
Jul 17, 1997·The New England Journal of Medicine·F Holleman, J B Hoekstra
Jan 5, 2002·Diabetes Technology & Therapeutics·M K FrohnauerJ H Anderson
Jun 12, 1998·Archives of Disease in Childhood·J P Shield, J D Baum
May 24, 2012·The AAPS Journal·Wolfgang F RichterMarilyn E Morris
Sep 30, 2005·Anesthesia and Analgesia·Erinn T RhodesJoseph I Wolfsdorf
May 11, 2006·PLoS Medicine·Andrew C AhnRussell S Phillips
Oct 31, 2002·Clinical Pharmacokinetics·Paris Roach, James R Woodworth
Dec 14, 2007·Clinical Pharmacokinetics·Reinhard H A Becker, Annke D Frick
Aug 10, 2000·Drugs·J M Chehade, A D Mooradian
Nov 13, 2015·Expert Review of Medical Devices·Eda CengizWilliam V Tamborlane
Jul 25, 2003·Expert Opinion on Pharmacotherapy·Simon Heller
Jul 5, 2005·Expert Opinion on Investigational Drugs·E A Gale
Jul 24, 1998·Annals of Medicine·V A Koivisto
May 12, 2012·Endocrinology and Metabolism Clinics of North America·Carla A Borgoño, Bernard Zinman
May 15, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leonid KaganAmnon Hoffman
Feb 19, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·J-W ChenJ S Christiansen
Jun 11, 2004·Acta Paediatrica·R M Williams, D B Dunger
Jun 11, 2003·Diabetes, Obesity & Metabolism·Jian-Wen ChenTorsten Lauritzen
Sep 17, 2009·Pediatric Diabetes·Hans-Jacob BangstadRagnar Hanas
Apr 24, 2007·Pediatric Diabetes·Hans-Jacob BangstadUNKNOWN International Society for Pediatric and Adolescent Diabetes
Mar 24, 2006·Journal of Advanced Nursing·Hyunsook Shin, Mi Ja Kim
Jun 17, 2006·Diabetes, Obesity & Metabolism·A H Barnett
Apr 1, 2005·Drug Discovery Today. Technologies·Danielle N McLennanSusan A Charman
Sep 4, 2015·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Ahmed H El-Laboudi, Nick Oliver
Jun 25, 2002·Best Practice & Research. Clinical Gastroenterology·Anders Lindholm
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Miguel N HissaLinda P Fredrickson
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·J A DavidsonJ V Santiago
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R JamalB H Ginsberg
May 24, 2014·Diabetes Care·Lee Ann Trimble, Graydon S Meneilly
Sep 7, 2016·Mayo Clinic Proceedings·Anders H FridKenneth W Strauss

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