Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Silvia LopaLaura de Girolamo

Abstract

Osteoarthritis (OA) represents a relevant social and economic burden worldwide. "Mesenchymal stem cells" or, as recently proposed, "medicinal signaling cells" (MSCs) have been recently introduced as injective treatments for OA with the aim of restoring joint homeostasis. The aim of this review is to provide the reader with the tools necessary to interpret the currently available clinical data, focusing on the MSC mechanisms of action which might help to clarify what we should expect from this treatment. Clinical studies reporting MSC injections for the treatment of knee OA, either freshly isolated or culture-expanded cells, have been included and commented in relation to the supposed therapeutic effect that MSCs might exert giving their supposed mode of actions. The majority of the studies reports significant improvements in terms of pain and knee function compared to baseline values, up to 24 months of follow-up. Although these data support the expected therapeutic effect of this therapy giving the features of these cells, only 14% of the studies present a control group and more than one-third of them report the results on less than ten patients. Despite the constant presence of positive and satisfactory results in the studies...Continue Reading

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Citations

Dec 1, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·J VegaM Dalmau-Pastor
Feb 23, 2020·The Journal of Bone and Joint Surgery. American Volume·C Thomas VangsnessMichael J Daley
Jul 9, 2020·American Journal of Physiology. Cell Physiology·Chiara ScognamiglioGianluca Cidonio
Nov 7, 2019·Journal of Clinical Medicine·Daniele D'ArrigoGiuseppe Filardo
Feb 2, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Emily Claire DoyleSamantha Louise Wilson
Aug 2, 2019·Orthopaedic Journal of Sports Medicine·UNKNOWN Arthroscopy Association of CanadaBogdan Matache
Oct 8, 2020·Journal of Orthopaedic Surgery and Research·Rodrigo MardonesNicola Maffulli
Feb 29, 2020·Regenerative Therapy·Edward H NtegeYusuke Shimizu
Mar 13, 2021·World Journal of Stem Cells·José Fábio Santos Duarte LanaMarco Antonio Percope de Andrade
Mar 28, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonGiuseppe Filardo
Oct 3, 2020·The Journal of Rheumatology·Jennifer GongYuanyuan Wang
May 28, 2021·British Journal of Sports Medicine·Tom Gh WiggersMaarten H Moen
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Aug 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Umberto LavagnoloAndrea Sbarbati

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT00550524
NCT01183728
NCT01586312
NCT02123368
NCT01453738
NCT02118519
NCT01931007
NCT01585857
NCT01809769
NCT02357485

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