PMID: 8971639Oct 1, 1996Paper

Injury-induced remodelling and regeneration of the ribbon presynaptic terminal in vitro

Journal of Neurocytology
M Nachman-Clewner, Ellen Townes-Anderson

Abstract

The neuronal response to axonal injury may relate to the type of insult incurred. Recently, neuritic and presynaptic varicosity regeneration by isolated adult salamander photoreceptors was demonstrated. We have used this system to compare the rod photoreceptor response to two types of injury: denervation/detargeting, the removal of pre- and postsynaptic partners from the axon terminal, and axotomy, the removal of the axon terminal itself. Cells were followed with time-lapse video microscopy for 24-48 h in culture and immunolabelled for SV2 or synaptophysin to identify synaptic vesicle-containing varicosities. Although all injured cells responded with regenerative growth, denervated/detargeted photoreceptors (i.e. neurons which retain their axon terminal) grew 80% more processes and fourfold more presynaptic varicosities than axotomized neurons. In cells which retained their original axon and terminal, varicosity formation generally began with axon retraction. Retraction was followed by elaboration of a lamellipodium and, by 48 h, development of varicosity-bearing neurites from the lamellipodium. Synaptic vesicle protein localization in denervated/detargeted cells paralleled axon terminal reorganization. Axotomized cells, in con...Continue Reading

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Citations

Oct 23, 2002·Journal of Neurochemistry·Peter D AlfinitoEllen Townes-Anderson
Apr 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter D Alfinito, Ellen Townes-Anderson
Jan 25, 2002·The Journal of Comparative Neurology·Haidong YangDavid M Sherry
Jun 12, 2013·The Journal of Comparative Neurology·James H PetersKrzysztof Czaja
Dec 14, 1999·The Journal of Comparative Neurology·M Nachman-ClewnerE Townes-Anderson
May 22, 2019·Investigative Ophthalmology & Visual Science·Weiwei WangEllen Townes-Anderson
Jul 6, 2014·Biofabrication·Anil B ShriraoEllen Townes-Anderson
Feb 7, 2001·Journal of Neurochemistry·P D Alfinito, E Townes-Anderson

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