Abstract
Restricted cochlear lesions in adult animals, causing partial deafness, result in a reorganization of primary auditory cortex (AI) such that the region deprived of its normal input by the lesion is occupied by an expanded representation of peri-lesion cochlear regions, and hence of peri-lesion frequencies. One possible mechanism underlying the change in frequency responsiveness involved in such reorganization is that inputs to the cortical neurons at frequencies at and near their "new" post-lesion characteristic frequencies (CFs) are normally present but suppressed by inhibition, and are "unmasked" by the effects of the lesion. Evidence in support of this explanation is provided by two-tone forward-masking experiments which reveal that many AI neurons receive surround inhibitory input. When input to such neurons at their CF is reduced by an intense temporary-threshold-shift (TTS)-inducing stimulus, the response areas of some neurons expand into the region of their inhibitory surrounds, the effect that would be expected if unmasking were involved in cortical reorganization. In other neurons, however, response areas contracted after the TTS-inducing stimulation. Although unmasking of normally-inhibited inputs is likely to contrib...Continue Reading
References
Mar 12, 1992·Nature·C D Gilbert, T N Wiesel
Jul 1, 1991·Hearing Research·R V HarrisonR J Mount
Feb 1, 1991·Journal of Neurophysiology·M B Calford, R Tweedale
Jan 1, 1991·Annual Review of Neuroscience·J H Kaas
Apr 15, 1989·The Journal of Comparative Neurology·D Robertson, D R Irvine
Apr 20, 1984·The Journal of Comparative Neurology·M M MerzenichJ M Zook
Jan 1, 1995·Annual Review of Neuroscience·N M Weinberger
May 1, 1995·Journal of Neurophysiology·M B Calford, M N Semple
Feb 1, 1995·Neuroscience Research·N Suga
Aug 1, 1993·Neuroscience·M B CalfordD R Irvine
Dec 1, 1993·The Journal of Comparative Neurology·R RajanP Heil
Mar 15, 1993·The Journal of Comparative Neurology·J F WillottS L McFadden
Feb 1, 1993·Journal of Neurophysiology·S A ShammaH Versnel
Oct 1, 1996·Clinical and Experimental Pharmacology & Physiology·D R Irvine, R Rajan
Nov 1, 1958·Journal of Neurophysiology·Y KATSUKIT WATANABE
Citations
Aug 30, 2000·Hearing Research·J A KaltenbachC E Afman
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophia VinogradovEtienne de Villers-Sidani
Jan 29, 2008·Cerebral Cortex·Vibhakar C KotakDan H Sanes
Feb 18, 2010·Future Neurology·Anne E TakesianDan H Sanes
Nov 3, 2006·Hearing Research·Nathan WeiszArnaud Norena
Oct 7, 2004·Neuroscience·C C LeeJ A Winer
Jan 21, 2000·The Journal of the Acoustical Society of America·P A Busby, G M Clark
Aug 31, 2004·Journal of Neuroscience Research·J J KimS J Potashner
Jan 27, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hilke BartelsFrans W J Albers
May 8, 2015·PloS One·Alwina SteinChristo Pantev