Injury prediction and vulnerability assessment using strain and susceptibility measures of the deep white matter

Biomechanics and Modeling in Mechanobiology
Wei ZhaoSongbai Ji

Abstract

Reliable prediction and diagnosis of concussion is important for its effective clinical management. Previous model-based studies largely employ peak responses from a single element in a pre-selected anatomical region of interest (ROI) and utilize a single training dataset for injury prediction. A more systematic and rigorous approach is necessary to scrutinize the entire white matter (WM) ROIs as well as ROI-constrained neural tracts. To this end, we evaluated injury prediction performances of the 50 deep WM regions using predictor variables based on strains obtained from simulating the 58 reconstructed American National Football League head impacts. To objectively evaluate performance, repeated random subsampling was employed to split the impacts into independent training and testing datasets (39 and 19 cases, respectively, with 100 trials). Univariate logistic regressions were conducted based on training datasets to compute the area under the receiver operating characteristic curve (AUC), while accuracy, sensitivity, and specificity were reported based on testing datasets. Two tract-wise injury susceptibilities were identified as the best overall via pair-wise permutation test. They had comparable AUC, accuracy, and sensitivi...Continue Reading

References

Nov 25, 2003·Neurosurgery·Elliot J PellmanUNKNOWN Committee on Mild Traumatic Brain Injury, National Football League
Jun 8, 2004·Journal of Biomechanical Engineering·Liying ZhangAlbert I King
Aug 1, 2006·Journal of Magnetic Resonance Imaging : JMRI·Michael H ChappellRichard Watts
Sep 9, 2006·Journal of Neurotrauma·D Kacy Cullen, Michelle C LaPlaca
Jun 15, 2007·Computer Methods in Biomechanics and Biomedical Engineering·Andrew E AndersonJeffrey A Weiss
Sep 18, 2007·Brain : a Journal of Neurology·Marilyn F KrausDeborah M Little
Oct 27, 2007·Journal of Biomechanics·Arash A SabetPhilip V Bayly
May 8, 2008·Accident; Analysis and Prevention·Daniel MarjouxRémy Willinger
Apr 1, 1946·Journal of Economic Entomology·F WILCOXON
Apr 9, 2011·Biomechanics and Modeling in Mechanobiology·Rika M Wright, K T Ramesh
Oct 14, 2011·Annals of Biomedical Engineering·Hideyuki Kimpara, Masami Iwamoto
Oct 14, 2011·Annals of Biomedical Engineering·Jonathan G BeckwithJeffrey J Chu
Nov 22, 2011·Journal of the Mechanical Behavior of Biomedical Materials·Simon ChatelinRémy Willinger
Mar 22, 2012·Brain Imaging and Behavior·Erin D Bigler, William L Maxwell
Mar 24, 2012·Annals of Biomedical Engineering·Ashley A WeaverJoel D Stitzel
Sep 7, 2012·Journal of Neurotrauma·Andrew GardnerDerek K Jones
Sep 21, 2012·Journal of Neurotrauma·Rika M WrightKaliat T Ramesh
Jul 13, 2013·Medicine and Science in Sports and Exercise·Mari A AllisonKristy B Arbogast
Sep 26, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Debasis SahooRémy Willinger
Sep 26, 2013·Journal of Biomechanical Engineering·Haojie MaoKing H Yang
Mar 13, 2014·Biomechanics and Modeling in Mechanobiology·Songbai JiThomas W McAllister
Dec 3, 2014·Annals of Biomedical Engineering·Songbai Ji, Wei Zhao
Dec 24, 2014·Annals of Biomedical Engineering·Fidel HernandezDavid B Camarillo
Jan 15, 2016·Biomechanics and Modeling in Mechanobiology·Logan E MillerJoel D Stitzel
Apr 4, 2016·Accident; Analysis and Prevention·Debasis SahooRémy Willinger

❮ Previous
Next ❯

Citations

Feb 23, 2018·Annals of Biomedical Engineering·Jonathan G BeckwithRichard M Greenwald
Nov 1, 2018·Annals of Biomedical Engineering·Wei Zhao, Songbai Ji
Nov 9, 2017·Journal of Biomechanical Engineering·Lee F GablerMatthew B Panzer
Sep 1, 2017·Biomechanics and Modeling in Mechanobiology·Calvin KuoDavid B Camarillo
Dec 8, 2019·Biomechanics and Modeling in Mechanobiology·Marzieh HajiaghamemarSusan S Margulies
Nov 24, 2019·Scientific Reports·Shaoju WuSongbai Ji
Apr 30, 2020·Annual Review of Biomedical Engineering·Eric A NaumanPaul S Auerbach
Nov 25, 2019·Biomechanics and Modeling in Mechanobiology·Shaoju WuSongbai Ji
May 1, 2020·Frontiers in Bioengineering and Biotechnology·Erin D AndersonDavid F Meaney
Jul 16, 2017·Annals of Biomedical Engineering·Wei ZhaoSongbai Ji
Dec 6, 2018·Annals of Biomedical Engineering·Lee F GablerMatthew B Panzer
Dec 7, 2018·Annals of Biomedical Engineering·Harsha T GarimellaReuben H Kraft
Nov 1, 2020·Journal of Neurotrauma·Kianoosh GhaziSongbai Ji
Dec 2, 2020·Annals of Biomedical Engineering·Logan E MillerJoel D Stitzel
Jan 20, 2021·Journal of the Mechanical Behavior of Biomedical Materials·David A Bruneau, Duane S Cronin
Jan 16, 2021·Journal of Neurotrauma·Zhou ZhouMichael Zeineh
Apr 25, 2021·Annals of Biomedical Engineering·Jeffrey S BrooksJames P Dickey
Oct 26, 2021·Frontiers in Bioengineering and Biotechnology·Andrea MenichettiNele Famaey
Oct 8, 2021·Journal of Neurotrauma·Zhou ZhouMichael Zeineh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.