Injury severity and serum amyloid A correlate with plasma oxidation-reduction potential in multi-trauma patients: a retrospective analysis.

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Leonard T RaelDavid Bar-Or

Abstract

In critical injury, the occurrence of increased oxidative stress or a reduced antioxidant status has been observed. The purpose of this study was to correlate the degree of oxidative stress, by measuring the oxidation-reduction potential (ORP) of plasma in the critically injured, with injury severity and serum amyloid A (SAA) levels. A total of 140 subjects were included in this retrospective study comprising 3 groups: healthy volunteers (N = 21), mild to moderate trauma (ISS < 16, N = 41), and severe trauma (ISS >or= 16, N = 78). For the trauma groups, plasma was collected on an almost daily basis during the course of hospitalization. ORP analysis was performed using a microelectrode, and ORP maxima were recorded for the trauma groups. SAA, a sensitive marker of inflammation in critical injury, was measured by liquid chromatography/mass spectrometry. ORP maxima were reached on day 3 (+/- 0.4 SEM) and day 5 (+/- 0.5 SEM) for the ISS < 16 and ISS >or= 16 groups, respectively. ORP maxima were significantly higher in the ISS < 16 (-14.5 mV +/- 2.5 SEM) and ISS >or= 16 groups (-1.1 mV +/- 2.3 SEM) compared to controls (-34.2 mV +/- 2.6 SEM). Also, ORP maxima were significantly different between the trauma groups. SAA was significan...Continue Reading

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Citations

Apr 24, 2016·Free Radical Biology & Medicine·Nathan J WhiteDominic Chung
Jun 5, 2016·Fertility and Sterility·Ashok AgarwalEdmund Sabanegh
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Kimberly B BjugstadDavid Bar-Or
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Jan 28, 2021·The Journal of Experimental Biology·Daniella E ChusydJanine L Brown
Mar 5, 2021·Investigative and Clinical Urology·Mitsuru NagoYasushi Yumura

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