Abstract
In critical injury, the occurrence of increased oxidative stress or a reduced antioxidant status has been observed. The purpose of this study was to correlate the degree of oxidative stress, by measuring the oxidation-reduction potential (ORP) of plasma in the critically injured, with injury severity and serum amyloid A (SAA) levels. A total of 140 subjects were included in this retrospective study comprising 3 groups: healthy volunteers (N = 21), mild to moderate trauma (ISS < 16, N = 41), and severe trauma (ISS >or= 16, N = 78). For the trauma groups, plasma was collected on an almost daily basis during the course of hospitalization. ORP analysis was performed using a microelectrode, and ORP maxima were recorded for the trauma groups. SAA, a sensitive marker of inflammation in critical injury, was measured by liquid chromatography/mass spectrometry. ORP maxima were reached on day 3 (+/- 0.4 SEM) and day 5 (+/- 0.5 SEM) for the ISS < 16 and ISS >or= 16 groups, respectively. ORP maxima were significantly higher in the ISS < 16 (-14.5 mV +/- 2.5 SEM) and ISS >or= 16 groups (-1.1 mV +/- 2.3 SEM) compared to controls (-34.2 mV +/- 2.6 SEM). Also, ORP maxima were significantly different between the trauma groups. SAA was significan...Continue Reading
References
Sep 1, 1972·The Journal of Surgical Research·H M Shapiro
May 1, 1996·The American Journal of Clinical Nutrition·C J SchorahA Bodenham
Jul 1, 1996·Critical Care Medicine·H C CowleyD K Menon
Jan 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M T CaslD Simić
Feb 1, 1996·Gut·A J WaringM F Dixon
Sep 8, 1998·The Biochemical Journal·L E Jensen, A S Whitehead
Jul 13, 2000·Critical Care Medicine·J M Alonso de VegaL F Carbonell
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·M C PolidoriB Frei
Dec 12, 2002·Chest·John D LangSadis Matalon
Jan 7, 2003·Toxicologic Pathology·Ron Kohen, Abraham Nyska
Feb 28, 2003·FEBS Letters·Urban A KiernanRandall W Nelson
May 30, 2003·Intensive Care Medicine·Cristiane RitterFelipe Dal-Pizzol
Jul 29, 2003·Current Opinion in Critical Care·Robin Lovat, Jean-Charles Preiser
Feb 6, 2004·Critical Care Medicine·Ori D Rotstein
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Erich RothBarbara Wessner
Jul 2, 2005·Annals of Clinical Biochemistry·Vinita MishraAlan Shenkin
Jul 9, 2005·Critical Care Medicine·David Bar-OrMichael L Craun
Jan 31, 2006·Free Radical Biology & Medicine·Ettore CrimiClaudio Napoli
Feb 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sheldon Magder
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Thierry LemineurJean-Charles Preiser
Jul 31, 2007·Biochemical and Biophysical Research Communications·Leonard T RaelDavid Bar-Or
Aug 19, 2007·Cell·Namakkal S RajasekaranIvor J Benjamin
Sep 7, 2007·Neurosurgery·Barbara TavazziGiuseppe Lazzarino
Mar 26, 2009·Journal of Neurotrauma·Leonard T RaelDavid Bar-Or
Citations
Jan 14, 2016·Journal of Neurotrauma·Nuria VillalbaKalev Freeman
Apr 24, 2016·Free Radical Biology & Medicine·Nathan J WhiteDominic Chung
Jun 5, 2016·Fertility and Sterility·Ashok AgarwalEdmund Sabanegh
Sep 20, 2016·Oxidative Medicine and Cellular Longevity·Kimberly B BjugstadDavid Bar-Or
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Nathan J WhiteAndrew P Cap
Mar 16, 2017·Andrologia·A AgarwalE Sabanegh
Mar 21, 2012·The Journal of International Medical Research·M T GokdemirM E Boleken
Jul 15, 2017·Shock·Kelsey PrestonKalev Freeman
Oct 12, 2018·PloS One·Luis ServiaJavier Trujillano
Nov 22, 2019·The World Journal of Men's Health·Christopher DouglasAshok Agarwal
Sep 12, 2019·Nutrients·Aileen HillChristian Stoppe
Mar 7, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Sarah Sophie NagelGabriel Hundeshagen
Aug 1, 2018·Nutrients·Aileen HillChristian Stoppe
Apr 3, 2018·Redox Report : Communications in Free Radical Research·David PolsonKalev Freeman
May 24, 2019·BioMed Research International·Evan WickerSonia Villapol
Feb 12, 2020·Journal of Neurotrauma·Stuart J McDonaldFrances Corrigan
Nov 2, 2017·Pediatric Cardiology·Amy E SchmidtJill M Cholette
May 11, 2019·Nutrients·Sander RozemeijerHeleen M Oudemans-van Straaten
Jan 28, 2021·The Journal of Experimental Biology·Daniella E ChusydJanine L Brown
Jan 23, 2021·Antioxidants·Alex G GauthierLin L Mantell
Feb 13, 2021·Injury·Pamela BourgDavid Bar-Or
Mar 5, 2021·Investigative and Clinical Urology·Mitsuru NagoYasushi Yumura
Aug 10, 2021·Intensive Care Medicine Experimental·Sander RozemeijerAngelique M E de Man