Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease

Mediators of Inflammation
José L ReyesAlicia Vázquez Mendoza

Abstract

Dry eye disease (DED) is the most common ocular disease and affects millions of individuals worldwide. DED encompasses a heterogeneous group of diseases that can be generally divided into two forms including aqueous-deficient and evaporative DED. Evidence suggests that these conditions arise from either failure of lacrimal gland secretion or low tear film quality. In its secondary form, DED is often associated with autoimmune diseases such as Sjögren's syndrome and rheumatoid arthritis. Current treatment strategies for DED are limited to anti-inflammatory medications that target the immune system as the source of deleterious inflammation and tissue injury. However, there is a lack of understanding of the underlying pathogenesis of DED, and subsequently, there are very few effective treatment strategies. The gap in our knowledge of the etiology of primary DED is in part because the majority of research in DED focused on secondary autoimmune causes. This review focuses on what is currently understood about the contribution of innate and adaptive immune cell populations in the pathogenesis of DED and highlights the need to continue investigating the central role of immunity driving DED.

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Citations

Feb 26, 2020·Eye & Contact Lens·Neeta RoyPenny A Asbell
Jun 27, 2019·Journal of Immunology Research·Long ShenVatinee Y Bunya
Nov 25, 2018·Metabolites·Paul L WoodLynda M J Miller
Feb 22, 2021·The Ocular Surface·Royce B ParkJennifer Park
Oct 5, 2020·Experimental Eye Research·Y Wei, P A Asbell
Apr 17, 2021·The Ocular Surface·Archana Padmanabhan NairSwaminathan Sethu
Jul 13, 2021·PloS One·Vannarut SatitpitakulThanachaporn Kittipibul
Jul 7, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eva HernandezMarc Labetoulle
Sep 30, 2021·European Journal of Ophthalmology·Stefano BarabinoMaurizio Rolando

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Methods Mentioned

BETA
biopsies
flow cytometry
biopsy

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