Abstract
Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness. While treatments, both gene therapy-based and drug-based, have been developed to slow or halt disease progression and prevent further blindness, only a small handful of the forms of RDs have treatments available, which are primarily for recessively inherited forms. Using immunohistochemical methods coupled with electroretinography, optical coherence tomography, and fluorescein angiography, we show that in rhodopsin mutant mice, the involvement of both the innate and the autoimmune systems could be a strong contributing factor in disease progression and pathogenesis. Herein, we show that monocytic phagocytosis and inflammatory cytokine release along with protein citrullination, a major player in forms of autoimmunity, work to enhance the progression of RD associated with a rhodopsin mutation.
References
Apr 3, 1999·Human Mutation·D A BessantS S Bhattacharya
Apr 3, 1999·Human Mutation·N RabenP H Plotz
Apr 22, 2005·The Journal of Comparative Neurology·Anthony P NicholasScott R Barnum
May 19, 2005·Arthritis Research & Therapy·Karin LundbergHelena Erlandsson Harris
May 26, 2006·Investigative Ophthalmology & Visual Science·Sanjoy K BhattacharyaJohn W Crabb
Jul 18, 2008·Progress in Retinal and Eye Research·Anneke I den HollanderFrans P M Cremers
Apr 25, 2009·IUBMB Life·Sanjoy K Bhattacharya
Feb 2, 2011·PloS One·Aurora M FontainhasWai T Wong
Jul 19, 2011·The American Journal of Pathology·Lian ZhaoWai T Wong
Jan 19, 2012·International Review of Cell and Molecular Biology·T J Hollingsworth, Alecia K Gross
May 9, 2012·Journal of Autoimmunity·Nimish K AcharyaRobert G Nagele
Nov 24, 2012·Biopolymers·Kevin L Bicker, Paul R Thompson
Mar 5, 2013·Nature Structural & Molecular Biology·Nadia J KershawJeffrey J Babon
Apr 9, 2013·Experimental Eye Research·Vera L BonilhaJoe G Hollyfield
Aug 14, 2013·The Journal of Biological Chemistry·T J Hollingsworth, Alecia K Gross
Dec 3, 2013·Annals of the Rheumatic Diseases·Nishant Dwivedi, Marko Radic
Mar 29, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nishant DwivediMarko Radic
Jul 4, 2015·EMBO Molecular Medicine·Lian ZhaoWai T Wong
Dec 31, 2015·PloS One·Alessandro IannacconeUNKNOWN Health ABC study
Oct 22, 2016·Arthritis Research & Therapy·Sanna TurunenPetri Lehenkari
Dec 19, 2016·Experimental Eye Research·Alessandro IannacconeFrancesco Giorgianni
Mar 21, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kasra A RezaeiRuikang K Wang
Oct 25, 2017·Cell and Tissue Research·Sabrina ReinehrStephanie C Joachim
Aug 4, 2018·Investigative Ophthalmology & Visual Science·T J HollingsworthAlessandro Iannaccone
Feb 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Michael LandowskiCatherine Bowes Rickman
Mar 21, 2019·Scientific Reports·Kaitryn E RonningMarie E Burns
May 18, 2019·PloS One·Zhigang LuPeter X Shaw
Aug 6, 2019·Frontiers in Immunology·Yvette WooffNilisha Fernando
Aug 29, 2019·Current Molecular Medicine·Naima MansoorHumaira Ayub
Sep 11, 2019·Progress in Retinal and Eye Research·Yusuke MurakamiKoh-Hei Sonoda
Sep 19, 2019·Acta Ophthalmologica·Quan-Yong YiLingyun Cheng
Oct 23, 2019·International Journal of Molecular Sciences·Teresa TsaiStephanie C Joachim
Dec 31, 2019·Advances in Experimental Medicine and Biology·Alessandro Iannaccone, Marko Z Radic