Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV

Reviews in Medical Virology
Abdellatif Bouayad

Abstract

SARS-CoV-2 virus, a member of the Coronaviridae family, causes Covid-19 pandemic disease with severe respiratory illness. Multiple strategies enable SARS-CoV-2 to eventually overcome antiviral innate immune mechanisms which are important components of viral pathogenesis. This review considers several mechanisms of SARS-CoV-2 innate immune evasion including suppression of IFN-α/β production at the earliest stage of infection, mechanisms that exhaust natural killer cell-mediated cytotoxicity, overstimulation of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS-CoV is made. Greater knowledge of these and other immune evasion tactics may provide us with improved possibilities for research into this novel deadly virus.

References

Nov 1, 2001·Respiratory Research·R S Peebles, B S Graham
Mar 20, 2004·Emerging Infectious Diseases·Lisa E HensleyThomas W Geisbert
Dec 4, 2004·Nature Medicine·J S M PeirisK Y Yuen
Jan 1, 2005·Genomics, Proteomics & Bioinformatics·Yongwu HuHuanming Yang
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Yong JiangPeng Deng
Aug 13, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Zhongping HeDominic E Dwyer
Aug 17, 2005·The Journal of Experimental Medicine·Carine Asselin-Paturel, Giorgio Trinchieri
Aug 27, 2005·World Journal of Gastroenterology : WJG·Shi-Yan YuZheng-Hong Yuan
Dec 3, 2005·Proceedings of the American Thoracic Society·Thomas R Martin, Charles W Frevert
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jung-Yien ChienPan-Chyr Yang
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Mar 7, 2008·Cytokine & Growth Factor Reviews·Volker Thiel, Friedemann Weber
Mar 12, 2008·The Journal of Experimental Medicine·Emma J PetrieJamie Rossjohn
Mar 28, 2008·Journal of Virology·Benjamin W NeumanPeter Kuhn
Jul 1, 2008·Veterinary Pathology·J M A van den BrandT Kuiken
Jul 15, 2009·Cell·Herbert W VirginRafi Ahmed
Aug 19, 2009·Biochemical and Biophysical Research Communications·Himanshu KumarShizuo Akira
Feb 9, 2010·PLoS Pathogens·Saskia L SmitsBart L Haagmans
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Jan 12, 2011·Annual Review of Immunology·Beckley K DavisJenny P-Y Ting
Oct 14, 2011·Viruses·Mikayla R ThompsonKatherine A Fitzgerald
May 4, 2012·Journal of Virology·Mariana Mesel-LemoineFrédéric Tangy
May 11, 2012·Current Opinion in Virology·Allison L Totura, Ralph S Baric
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tomohiko MurakamiTiffany Horng
Jun 29, 2012·The Journal of General Virology·Anna M GramMaaike E Ressing
Sep 22, 2012·Annual Review of Microbiology·Akiko Iwasaki

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Citations

Feb 14, 2021·International Immunopharmacology·Masoomeh MasoomikarimiReza Jafari
Feb 23, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marina MuñozJuan David Ramírez
Jun 29, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Rohan AmeratungaSee-Tarn Woon
Aug 28, 2021·Signal Transduction and Targeted Therapy·Yu-Wen ZhouXue-Lei Ma

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