Innate Immune Influences on the Gut Microbiome: Lessons from Mouse Models

Trends in Immunology
Susan J RobertsonDana J Philpott

Abstract

The gut microbiota is important in health and disease. Whereas the intestinal immune system has evolved to protect the mucosal barrier against pathogens, there is much interest in understanding how it influences the composition and functions of resident microbial communities. Overall, host innate immunity exerts little influence on the microbiota at homeostasis, but increases upon immune activation and the onset of inflammation, as well as in the presence of certain members of the microbiota. However, many experiments have not adequately incorporated study design to detect such immune influences, including using proper control groups, precise sampling and timing, and measures beyond broad-scale descriptions of dysbiosis for microbial analysis. We discuss these and other challenges in the context of current understanding of chronic inflammatory disease.

Citations

Mar 28, 2019·BioMed Research International·Fei ZhangDingren Bi
Jul 25, 2020·Mucosal Immunology·Qiaochu LinThierry Mallevaey
May 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hoon ChoiKyu-Won Kim
Aug 28, 2020·Current Opinion in Microbiology·Kathy D McCoy, Christina L Ohland
Aug 31, 2020·Brain, Behavior, and Immunity·Pedram HonarpishehBhanu P Ganesh
Apr 28, 2021·Annual Review of Immunology·Eduard AnsaldoYasmine Belkaid

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