Innate immune receptors in type 1 diabetes: the relationship to cell death-associated inflammation.

Biochemical Society Transactions
Tae Kang Kim, Myung-Shik Lee

Abstract

The importance of innate immunity in host defense and inflammatory responses has been clearly demonstrated after the discovery of innate immune receptors such as Toll-like receptors (TLRs) or Nucleotide-binding oligomerization domain-containing protein (Nod)-like receptors (NLRs). Innate immunity also plays a critical role in diverse pathological conditions including autoimmune diseases such as type 1 diabetes (T1D). In particular, the role of a variety of innate immune receptors in T1D has been demonstrated using mice with targeted disruption of such innate immune receptors. Here, we discuss recent findings showing the role of innate immunity in T1D that were obtained mostly from studies of genetic mouse models of innate immune receptors. In addition, the role of innate immune receptors involved in the pathogenesis of T1D in sensing death-associated molecular patterns (DAMPs) released from dead cells or pathogen-associated molecular patterns (PAMPs) will also be covered. Elucidation of the role of innate immune receptors in T1D and the nature of DAMPs sensed by such receptors may lead to the development of new therapeutic modalities against T1D.

References

Aug 1, 1993·Nature Genetics·S GhoshL B Peterson
Jan 1, 2000·Diabetes·J D TrudeauD T Finegood
Feb 19, 2000·Current Opinion in Immunology·B Beutler
Nov 4, 2000·The Journal of Biological Chemistry·N InoharaG Nuñez
Jul 30, 2002·Diabetes·Bronwyn A O'BrienDiane T Finegood
Apr 30, 2003·The Journal of Experimental Medicine·Benjamin N GantnerDavid M Underhill
May 27, 2003·Nature Reviews. Immunology·Naohiro Inohara, Gabriel Nuñez
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salah-Eddine Lamhamedi-CherradiYouhai H Chen
Nov 19, 2003·The Journal of Experimental Medicine·Shannon TurleyDiane Mathis
Dec 25, 2003·Diabetes·William H SchottEdward H Leiter
Dec 25, 2003·Diabetes·Helen E ThomasThomas W H Kay
Feb 9, 2005·Annals of the New York Academy of Sciences·Yongsoo ParkHyongdoo Shin
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sunshin KimMyung-Shik Lee
Apr 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arunika MukhopadhayaTeresa P DiLorenzo
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subha Karumuthil-MelethilChenthamarakshan Vasu
Jan 6, 2009·Annals of the New York Academy of Sciences·F Susan WongLi Wen
Apr 23, 2009·The Biochemical Journal·Himanshu KumarShizuo Akira
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Apr 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yiqun ZhangJan P Dutz
Apr 24, 2010·Immunity·John A Todd
Apr 27, 2010·Clinical and Experimental Immunology·H OkadaJ-F Bach
Apr 29, 2010·Seminars in Immunopathology·Sisko TauriainenHeikki Hyöty
Jul 16, 2010·Reviews in Medical Virology·Hela JaïdaneDidier Hober
Aug 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oliver T BurtonAnne Cooke
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa Deep Dixit
Mar 11, 2011·Science Translational Medicine·Gina S Garcia-RomoVirginia Pascual
Apr 19, 2011·Inflammation & Allergy Drug Targets·Yuxing ZhaoHelen E Thomas
Apr 19, 2011·Cytokine·Sridevi DevarajIshwarlal Jialal
May 17, 2011·Advances in Immunology·Dominik Schenten, Ruslan Medzhitov

❮ Previous
Next ❯

Citations

Aug 25, 2020·International Journal of Environmental Research·Walter Gottlieb Land
Aug 3, 2021·Frontiers in Immunology·Yang LiCong-Yi Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Opinion in Endocrinology, Diabetes, and Obesity
Steven C PinoRita Bortell
Current Diabetes Reports
James C Needell, Danny Zipris
Advances in Experimental Medicine and Biology
Danny Zipris
Translational Research : the Journal of Laboratory and Clinical Medicine
Susanne M CabreraMartin J Hessner
© 2022 Meta ULC. All rights reserved