Innate immune responses to environmental allergens.

Clinical Reviews in Allergy & Immunology
Henk F Kauffman

Abstract

Aero-allergens, including plant pollens, house dust mite particles, fungal spores, and mycelium fragments, are continuously inhaled and deposited on the airway mucosa. These particles and their soluble components actively interact with innate recognition systems present in the mucosal layer (e.g., surfactant proteins) and with various receptors present on a diversity of cells in the airways. Deposited particles are first removed by active transportation, the rate of which is either enhanced or inhibited by components present in the inhaled substances. Cleaning further depends on innate recognition, beginning with (a) soluble factors released into the mucosal surface layer that bind different bio-organic components; (b) innate receptors on phagocytic cells, alveolar macrophages, and dendritic monocytes; and (c) innate receptors on airway epithelial cells. Different innate receptor families (Toll-like receptors [TLRs], nucleotide-binding oligomerization domain receptors, and protein-activated receptors [PARs]) have been demonstrated on airway cells, including alveolar macrophages, monocytes, dendritic cells, and airway tissue cells (e.g., epithelial cells and mast cells). However, although the functional role of these receptors h...Continue Reading

Citations

Aug 19, 2007·Current Allergy and Asthma Reports·Horng-Der ShenHong Chou
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Yehuda Shoenfeld, M Eric Gershwin
Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Yaniv ShererYehuda Shoenfeld
Jan 17, 2008·Clinical Reviews in Allergy & Immunology·Uriel Katz, Yehuda Shoenfeld
Jan 15, 2008·Clinical Reviews in Allergy & Immunology·Pierre Youinou
Nov 19, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Estelle Cormet-BoyakaProsper N Boyaka
Jan 9, 2010·Medical Mycology·Steven P TempletonDetlef Schmechel
Feb 20, 2008·Scandinavian Journal of Immunology·E RedvallC Wennerås
Sep 1, 2015·Pediatric Clinics of North America·Jessica P Hollenbach, Michelle M Cloutier
Jun 16, 2015·BioMed Research International·Jhony Robison de OliveiraAlexandre de Paula Rogério
Feb 24, 2015·Brazilian Journal of Otorhinolaryngology·Wilma T Anselmo-LimaShirley Shizue Nagata Pignatari
Dec 14, 2017·Annual Review of Immunology·Michail S Lionakis, Stuart M Levitz
Dec 21, 2013·International Archives of Allergy and Immunology·Félix E Rivera-MarianiPatrick N Breysse
Oct 11, 2014·Environmental Health Perspectives·Watcharoot KanchongkittiphonWanda Phipatanakul
Feb 28, 2008·Nature Reviews. Immunology·Hamida Hammad, Bart N Lambrecht
Sep 2, 2009·Journal of Leukocyte Biology·Claudio Sorio, Paola Melotti
Oct 2, 2019·Disease-a-month : DM·Roua AzmehRobert D Lloyd
Feb 27, 2020·Brazilian Journal of Otorhinolaryngology·Lin LinGuangbin Sun

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