Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease

Drug Discovery Today. Disease Mechanisms
Keith D Roby, Anna Di Nardo

Abstract

Cathelicidin antimicrobial peptide is an important mediator of the innate immune response. In addition to its potent antimicrobial activity, cathelicidin has been shown to have chemoattractant and angiogenic properties. Recent research has demonstrated that, in addition to its aforementioned functions, cathelicidin plays an important role in the complex pathogenesis of several chronic inflammatory skin diseases. This review will present a concise overview of the role of cathelicidin in infection and in the development of atopic dermatitis, psoriasis, and rosacea. This understanding will direct future research efforts to identify therapeutic approaches that use cathelicidin as a novel drug itself, or aim to modify its expression and regulation.

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Citations

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Related Concepts

Dermatitis, Atopic
Psoriasis
Research
Immune Response
Cathelicidin antimicrobial peptide
Cathelicidin
Pathogenesis
Rosaceae (plant)
Protein Expression
Pharmacologic Substance

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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