Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

Viruses
Xiaobo LeiJianwei Wang

Abstract

Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. EVs, which are positive-sense single-stranded RNA viruses, trigger activation of the host antiviral innate immune responses through pathogen recognition receptors such as retinoic acid-inducible gene (RIG-I)-likeand Toll-like receptors. In turn, EVs have developed sophisticated strategies to evade host antiviral responses. In this review, we discuss the interplay between the host innate immune responses and EV infection, with a primary focus on host immune detection and protection against EV infection and viral strategies to evade these antiviral immune responses.

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Citations

Jul 7, 2017·Journal of Virology·Xiaobo LeiJianwei Wang
Sep 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Giel P GöertzGorben P Pijlman
Jan 7, 2020·The American Journal of Chinese Medicine·Meng-Jie WangYuan-Yuan Liu
May 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Bing MengBei Yang
Sep 25, 2018·Nucleic Acids Research·Zhaolong LiWenyan Zhang
Jun 26, 2020·Scientific Reports·Manel Essaidi-LaziosiCaroline Tapparel
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Mar 31, 2021·Chinese Journal of Natural Medicines·Yi-Meng WangWen-Bing Yao
Sep 7, 2021·Frontiers in Cellular and Infection Microbiology·Rui ZhangZhiwei Wu
Oct 10, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shan Nan ChenPin Nie

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