Innate immunity in Alzheimer's disease: the relevance of animal models?

Journal of Neural Transmission
Diana K Franco BocanegraDelphine Boche

Abstract

The mouse is one of the organisms most widely used as an animal model in biomedical research, due to the particular ease with which it can be handled and reproduced in laboratory. As a member of the mammalian class, mice share with humans many features regarding metabolic pathways, cell morphology and anatomy. However, important biological differences between mice and humans exist and must be taken into consideration when interpreting research results, to properly translate evidence from experimental studies into information that can be useful for human disease prevention and/or treatment. With respect to Alzheimer's disease (AD), much of the experimental information currently known about this disease has been gathered from studies using mainly mice as models. Therefore, it is notably important to fully characterise the differences between mice and humans regarding important aspects of the disease. It is now widely known that inflammation plays an important role in the development of AD, a role that is not only a response to the surrounding pathological environment, but rather seems to be strongly implicated in the aetiology of the disease as indicated by the genetic studies. This review highlights relevant differences in infla...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 1, 1991·Alzheimer Disease and Associated Disorders·P FrommeltR J Polinsky
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·D G DavisW R Markesbery
Jun 11, 1999·The American Journal of Pathology·M StalderM Jucker
Jul 11, 2000·Nature Genetics·C K LeeT A Prolla
May 30, 2001·Neurobiology of Aging·M N GordonG W Arendash
Jul 10, 2001·Aging : Clinical and Experimental Research·I McDowell
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tobias MoehlmannHarald Steiner
Jul 12, 2002·Annals of Neurology·Kathryn P RileyWilliam R Markesbery
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C HolmesV H Perry
Apr 2, 2004·Journal of Neuropathology and Experimental Neurology·Gabriella MarconFabrizio Tagliavini
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·Anja LambrechtsChristophe Ampe
Oct 29, 2004·The American Journal of Pathology·Arianna BellucciMaria Grazia Spillantini
Jan 26, 2005·The Journal of Clinical Investigation·Robert P BrendzaDavid M Holtzman
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuel ButtiniDora Games
Mar 23, 2006·The Journal of Biological Chemistry·Avik RoyKalipada Pahan
Jul 21, 2006·Brain : a Journal of Neurology·Henry EnglerAgneta Nordberg
Sep 20, 2006·Journal of Neurochemistry·Rebecca GriffinMarina A Lynch
Sep 29, 2006·Journal of Neuroinflammation·Carol A ColtonMichael P Vitek

❮ Previous
Next ❯

Citations

Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Solomon Habtemariam
Aug 5, 2017·The EMBO Journal·Hiroki SasaguriTakaomi C Saido
Feb 3, 2021·Brain : a Journal of Neurology·Iain J HartnellDelphine Boche
Jun 4, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ana Belen Lopez-RodriguezColm Cunningham
Sep 17, 2021·Neuropathology and Applied Neurobiology·James A R NicollDavid Hilton
Jul 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Delphine Boche, Marcia N Gordon

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
biopsies

Software Mentioned

PICALM

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.