Innate immunity in critical care

Seminars in Pediatric Infectious Diseases
M Michele Mariscalco

Abstract

Innate and adaptive immunity are required for effective control of infection. Numerous breakthroughs have been achieved in the last 15 years with regard to the functioning of the innate immune system. This article focuses on new paradigms of microorganism recognition, discusses recently described (or rediscovered) cytokines that provide further insight into the development of sepsis, and reviews both pro- and anti-inflammatory pathways for control of infection. Finally, it discusses what has and has not worked with regard to controlling inflammatory pathways in septic patients.

References

Mar 24, 1988·The New England Journal of Medicine·T I SørensenT W Teasdale
Apr 1, 1995·Nature Medicine·J O LundbergK Alving
Jul 8, 1999·Nature Medicine·B J CzermakP A Ward
Jul 10, 1999·Science·H WangK J Tracey
Aug 3, 2000·The New England Journal of Medicine·R Medzhitov, C Janeway
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Nov 10, 2001·Hematology·Mary C. DinauerDavid C. Dale
Jan 25, 2002·Nature·Michael Zasloff
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Louis VincentMarc-Jacques Dubois
Sep 12, 2002·Biochimica Et Biophysica Acta·Jinhua LuKenneth B M Reid
Dec 20, 2002·Nature·Kevin J Tracey
Mar 29, 2003·Physiological Reviews·Alan R BurnsDavid C Walker
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Maria DejaKlaus Lewandowski
Aug 15, 2003·The Cochrane Database of Systematic Reviews·R CarrC Doré
Sep 23, 2003·Nature Reviews. Immunology·Thierry Calandra, Thierry Roger
Dec 12, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kai Singbartl, Klaus Ley
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Feb 6, 2004·Critical Care Medicine·Steven OpalUNKNOWN Controlled Mortality Trial of Platelet-Activating Factor Acetylhydrolase in Severe Sepsis Investigators
Mar 3, 2004·Intensive Care Medicine·Ahmad D ChishtiSimon V Baudouin
Mar 18, 2004·Journal of Endotoxin Research·Zia Shariat-Madar, Alvin H Schmaier
May 20, 2004·JAMA : the Journal of the American Medical Association·Edward D VerrierUNKNOWN PRIMO-CABG Investigators
May 26, 2004·Molecular Immunology·Melanie L HartGregory L Stahl
Jun 5, 2004·Journal of Leukocyte Biology·Min-Fu Tsan, Baochong Gao
Jun 29, 2004·Molecular Immunology·Osnat Bohana-KashtanZvi Fishelson

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Citations

May 5, 2012·Neurochemistry International·Ibeth Guevara-Lora
Dec 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·François ProulxJacques Lacroix

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