Innate immunity in early chordates and the appearance of adaptive immunity

Comptes rendus biologies
L Du Pasquier

Abstract

In the urochordate Ciona intestinalis some membrane Immunoglobulin superfamily members with ancestral features of antigen receptors are homologs of vertebrate adhesion molecules acting as virus receptors. They include the following: the junction adhesion molecule (reovirus receptor) (JAM), the Cortical thymocyte marker of Xenopus (CTX family) (Coxsackie's virus receptor) and the poliovirus receptor (PVR). In humans these genes belong to the same linkage group, of which 4 paralogous groups exist. This situation is consistent with the notion that the Ciona set of genes would correspond to a preduplication state. In addition, the human region 3q13 and its paralogs, harbour genes remotely related to the nectin family that can be detected in Protostomes (human CRTAM and CD80-86 related to Drosophila Beat). In addition, this linkage group contains several CDs important for the immune system CD166, CD47 and many members of the tetraspanin family. The VC1-like core of the nectin is homologous to the VCI core of the MHC-linked tapasin and to the VC1 segments of, for example, specific antigen receptors of vertebrates, and could be related to a primitive antigen receptor gene. It is suggested that the virus binding property of the members...Continue Reading

References

Feb 1, 1995·Journal of Virology·E A TolskayaV I Agol
Nov 3, 1995·The Journal of Biological Chemistry·R G BootJ M Aerts
Mar 11, 1994·Cell·D L VauxA Strasser
Apr 1, 1996·European Journal of Immunology·I ChrétienL Du Pasquier
May 1, 1996·Research in Immunology·L DuPasquier, I Chrétien
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·C M AdemaE S Loker
Apr 1, 1998·European Journal of Immunology·J A HerbergJ Trowsdale
Dec 23, 1998·European Journal of Immunology·I ChrétienL Du Pasquier
May 13, 1999·Immunological Reviews·L Abi RachedP Pontarotti
Mar 10, 2001·Cell·E S BartonT S Dermody
Mar 29, 2002·European Journal of Immunology·Michelle S TengJohn Trowsdale

❮ Previous
Next ❯

Citations

Mar 31, 2010·Marine Biotechnology·Bergljot Magnadottir
Mar 7, 2014·Nitric Oxide : Biology and Chemistry·Cintia M de BarrosSilvana Allodi
Jul 24, 2013·Briefings in Functional Genomics·Bryan D HudsonGabriela G Loots
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Isabelle Jutras, Michel Desjardins
Oct 17, 2012·PloS One·Men Long LiongChoong Chin Liew
Nov 10, 2011·Viruses·Luis P Villarreal
May 1, 2009·Immunogenetics·Ivana ZucchettiLouis Du Pasquier
May 16, 2009·New Biotechnology·H Peter Vollmers, Stephanie Brändlein
Sep 11, 2007·Journal of Autoimmunity·H Peter Vollmers, Stephanie Brändlein
Sep 27, 2005·Immunological Reviews·Michel DesjardinsEtienne Gagnon
Jul 2, 2009·Annals of the New York Academy of Sciences·Nadia Danilova, Chris T Amemiya
Apr 19, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nadia Danilova
Dec 10, 2014·Nature Reviews. Genetics·Eugene V Koonin, Mart Krupovic
Jun 18, 2004·Immunological Reviews·Louis Du PasquierRosaria De Santis
May 28, 2013·International Journal of Molecular Sciences·Vicki M VelonasStephen J Assinder
Sep 8, 2011·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Marju Männiste, Peeter Hõrak
May 23, 2012·PloS One·Tuul SeppPeeter Hõrak
Feb 10, 2018·Evolution, Medicine, and Public Health·Robert BayersdorfFrancesco Catania
Aug 13, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaanus SuurväliPierre Boudinot
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark E DeVriesDavid J Kelvin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.