Innate immunological function of TH2 cells in vivo

Nature Immunology
Liying GuoWilliam E Paul

Abstract

Type 2 helper T cells (TH2 cells) produce interleukin 13 (IL-13) when stimulated by papain or house dust mite extract (HDM) and induce eosinophilic inflammation. This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs). While type 2 innate lymphoid cells (ILC2 cells) are the dominant innate producers of IL-13 in naive mice, we found here that helminth-infected mice had more TH2 cells compared to uninfected mice, and thes e cells became major mediators of innate type 2 responses. TH2 cells made important contributions to HDM-induced antigen-nonspecific eosinophilic inflammation and protected mice recovering from infection with Ascaris suum against subsequent infection with the phylogenetically distant nematode Nippostrongylus brasiliensis. Our findings reveal a previously unappreciated role for effector TH2 cells during TCR-independent innate-like immune responses.

References

Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·N R LynchM C DiPrisco
Nov 18, 1997·International Archives of Allergy and Immunology·E H ShinS Kojima
Mar 25, 1998·Current Biology : CB·G J McKenzieA N McKenzie
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Mar 23, 2000·The Journal of Experimental Medicine·M J TownsendA N McKenzie
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Apr 20, 2002·Science·Maria YazdanbakhshRonald van Ree
Jun 5, 2002·American Journal of Respiratory and Critical Care Medicine·Lyle J PalmerXiping Xu
Jul 27, 2005·Investigative Ophthalmology & Visual Science·Lisa SchopfAndrea Keane-Myers
May 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Francisco GuarnerGraham A W Rook
Feb 24, 2007·Nature Reviews. Immunology·Padraic G Fallon, Niamh E Mangan
Jun 5, 2007·Immunobiology·Elly van RietMaria Yazdanbakhsh
Jun 9, 2007·International Journal for Parasitology·Michelle L KnottLindsay A Dent
Nov 17, 2007·Nature Reviews. Immunology·Robert M AnthonyWilliam C Gause
Jan 3, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E PinelliH van Loveren
Oct 2, 2008·Nature Reviews. Drug Discovery·Rahul Kakkar, Richard T Lee
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Liying GuoWilliam Paul
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 13, 2010·Nature Reviews. Immunology·William Harnett, Margaret M Harnett
Mar 20, 2010·Nature Immunology·Steven F Ziegler, David Artis
Jan 10, 2012·Annual Review of Immunology·Hergen Spits, Tom Cupedo
Jan 24, 2012·Nature Immunology·See Heng WongAndrew N J McKenzie
Mar 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mélanie PicheryJean-Philippe Girard
Sep 11, 2012·Trends in Immunology·Liying GuoWilliam E Paul
Oct 4, 2014·Current Opinion in Immunology·Corinne Cayrol, Jean-Philippe Girard
Nov 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christian SchwartzDavid Voehringer

❮ Previous
Next ❯

Citations

Feb 9, 2016·Nature Reviews. Immunology·Matthew F KrummelAudrey Gérard
Jan 7, 2016·Current Opinion in Immunology·Nicholas D HuntingtonGabrielle T Belz
Apr 9, 2016·Trends in Immunology·Michael PeineMax Löhning
Feb 19, 2016·European Journal of Immunology·Hye Young KimRosemarie H Dekruyff
Apr 20, 2016·Nature Immunology·Sammy BedouiWolfgang Kastenmüller
May 30, 2016·The Journal of Allergy and Clinical Immunology·Jason P LynchSimon Phipps
Jun 4, 2016·Seminars in Immunopathology·Peter C Cook, Andrew S MacDonald
Apr 28, 2016·European Journal of Immunology·Kelly M Cautivo, Ari B Molofsky
Sep 16, 2016·PLoS Neglected Tropical Diseases·Neima BriggsPeter J Hotez
Dec 25, 2016·The Journal of Experimental Medicine·Jakob von MoltkeRichard M Locksley
Nov 20, 2016·European Journal of Immunology·Svenja SteinfelderSusanne Hartmann
Jun 29, 2017·Immunological Reviews·Clare M Lloyd, Sejal Saglani
Jun 29, 2017·Immunological Reviews·Masato Kubo
Jan 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcus J RobinsonGraham Le Gros
Dec 21, 2017·Intractable & Rare Diseases Research·Xiaodan ZhengChengfang Yao
Aug 31, 2017·Nature Reviews. Immunology·Richard L GieseckThomas A Wynn
Dec 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao LiuJoshua A Boyce
Mar 13, 2018·International Immunology·Masakatsu Yamashita, Makoto Kuwahara
Aug 30, 2017·Cold Spring Harbor Perspectives in Biology·Jinfang Zhu
Sep 23, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BoudaudMarek Rola-Pleszczynski
Feb 9, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kristina Johansson, Henry J McSorley
Sep 20, 2017·Nature Immunology·Bart N Lambrecht, Hamida Hammad
Aug 15, 2017·Molecular Medicine·Giulia MesianoDavide Ferrari
Jan 4, 2018·Mucosal Immunology·D SorobeteaR Grencis
Oct 31, 2017·Nature Reviews. Immunology·Jennifer A Walker, Andrew N J McKenzie
Jun 25, 2019·Frontiers in Immunology·Craig P McEnteeEd C Lavelle
Oct 31, 2018·Nature Communications·Marion RolotBenjamin G Dewals
May 30, 2020·Nature Reviews. Disease Primers·Kathryn J ElsePhilip J Cooper
Jun 25, 2020·The Journal of Experimental Medicine·Rod A RahimiAndrew D Luster
Jul 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kangyun WuMichael J Holtzman

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
PMA
PCR
genotyping
flow cytometry

Software Mentioned

FlowJo

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.