Innate Lymphocytes in Psoriasis.

Frontiers in Immunology
Barbara PoleseIrah L King

Abstract

Skin is a fundamental component of our host defense system that provides a dynamic physical and chemical barrier against pathogen invasion and environmental insults. Cutaneous barrier function is mediated by complex interactions between structural cells such as keratinocytes and diverse lineages of immune cells. In contrast to the protective role of these intercellular interactions, uncontrolled immune activation can lead to keratinocyte dysfunction and psoriasis, a chronic inflammatory disease affecting 2% of the global population. Despite some differences between human and murine skin, animal models of psoriasiform inflammation have greatly informed clinical approaches to disease. These studies have helped to identify the interleukin (IL)-23-IL-17 axis as a central cytokine network that drives disease. In addition, they have led to the recent description of long-lived, skin-resident innate lymphocyte and lymphoid cells that accumulate in psoriatic lesions. Although not completely defined, these populations have both overlapping and unique functions compared to antigen-restricted αβ T lymphocytes, the latter of which are well-known to contribute to disease pathogenesis. In this review, we describe the diversity of innate lymph...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Itohara, S Tonegawa
Jul 1, 1994·The Journal of Experimental Medicine·M C Coles, D H Raulet
Apr 1, 1994·Clinical and Experimental Immunology·P EttehadiR D Camp
Jul 1, 1996·The Journal of Experimental Medicine·J Alberola-IlaR M Perlmutter
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Apr 6, 1999·The Journal of Experimental Medicine·D ZengS Strober
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T L WalunasJ M Leiden
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BonishB J Nickoloff
Jul 4, 2001·European Journal of Immunology·E E RosmarakiJ P Di Santo
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L S MetelitsaR C Seeger
Apr 24, 2002·Science·Kamel BenlaghaAlbert Bendelac
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Oct 31, 2002·The Journal of Investigative Dermatology·Eva BuentkeAnnika Scheynius
May 29, 2003·Human Immunology·Tsuyoshi TakahashiHisamaru Hirai
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens SchümannH Robson MacDonald
Oct 28, 2003·Nature Immunology·Manfred BriglMichael B Brenner
Apr 7, 2005·Experimental Dermatology·Edward E S NieuwenhuisS Brian Wilson
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa M EbertBernhard Moser
Jun 22, 2007·Nature·Natalie A BorgJamie Rossjohn
Jul 21, 2007·Current Problems in Dermatology·E DikaH I Maibach
Dec 15, 2007·The Journal of Investigative Dermatology·Michael D GoberAnthony A Gaspari
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan M CoquetDale I Godfrey

❮ Previous
Next ❯

Citations

Sep 15, 2020·Frontiers in Immunology·Katelyn O'NeillNatasa Strbo
May 28, 2020·Frontiers in Immunology·Chunye Zhang, Ming Yang
Mar 16, 2021·Frontiers in Immunology·Umut Can KucuksezerGunnur Deniz
May 4, 2021·Frontiers in Immunology·Joshua R CoxAmy E Saunders

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
flow cytometry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Dermatological Research
Cheryl M SweeneyB Kirby
Dermatology : International Journal for Clinical and Investigative Dermatology
Farida BenhadouVéronique Del Marmol
Clinics in Dermatology
Amanda S Büchau, Richard L Gallo
Journal of the American Academy of Dermatology
Anthony A Gaspari
© 2021 Meta ULC. All rights reserved