Jun 22, 2016

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

Nature Immunology
Christoph S N Klose, David Artis

Abstract

Research over the last 7 years has led to the formal identification of innate lymphoid cells (ILCs), increased the understanding of their tissue distribution and has established essential functions of ILCs in diverse physiological processes. These include resistance to pathogens, the regulation of autoimmune inflammation, tissue remodeling, cancer and metabolic homeostasis. Notably, many ILC functions appear to be regulated by mechanisms distinct from those of other innate and adaptive immune cells. In this Review, we focus on how group 2 ILC (ILC2) and group 3 ILC (ILC3) responses are regulated and how these cells interact with other immune and non-immune cells to mediate their functions. We highlight experimental evidence from mouse models and patient-based studies that have elucidated the effects of ILCs on the maintenance of tissue homeostasis and the consequences for health and disease.

Mentioned in this Paper

Metabolic Process, Cellular
Research
Lymphocyte Subset
Immune Effector Cell
Regulation of Biological Process
Lymphoid Cells
CCL27
Tissue Homeostasis
Infiltrating Duct and Lobular Carcinoma
Autoimmune Diseases

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