Innate Lymphoid Cells Groups 1 and 3 in the Epithelial Compartment of Functional Human Intestinal Allografts

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P TalayeroE Paz-Artal

Abstract

We examined intraepithelial lymphocytes (IELs) in 213 ileal biopsies from 16 bowel grafts and compared them with 32 biopsies from native intestines. During the first year posttransplantation, grafts exhibited low levels of IELs (percentage of CD103(+) cells) principally due to reduced CD3(+) CD8(+) cells, while CD103(+) CD3(-) cell numbers became significantly higher. Changes in IEL subsets did not correlate with histology results, isolated intestine, or multivisceral transplants, but CD3(-) IELs were significantly higher in patients receiving corticosteroids. Compared with controls, more CD3(-) IELs of the grafts expressed CD56, NKp44, interleukin (IL)-23 receptor, retinoid-related orphan receptor gamma t (RORγt), and CCR6. No difference was observed in granzyme B, and CD3(-) CD127(+) cells were more abundant in native intestines. Ex vivo, and after in vitro activation, CD3(-) IELs in grafts produced significantly more interferon (IFN)-γ and IL-22, and a double IFNγ(+) IL-22(+) population was observed. Epithelial cell-depleted grafts IELs were cytotoxic, whereas this was not observed in controls. In conclusion, different from native intestines, a CD3(-) IEL subset predominates in grafts, showing features of natural killer cell...Continue Reading

References

Aug 2, 2003·Gastroenterology·Francisco LeónGarbiñe Roy
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Merja T AugustinTuomo J Karttunen
Jul 6, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fuju ChangHarriet Deere
Nov 19, 2005·Scandinavian Journal of Gastroenterology·Merja T AugustinTuomo J Karttunen
Sep 6, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J WangK A Newell
Jan 20, 2007·Digestive Diseases and Sciences·Cristina CamareroGarbiñe Roy
Sep 4, 2009·The New England Journal of Medicine·Thomas M Fishbein
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marina CellaMarco Colonna
Sep 14, 2010·Journal of Immunological Methods·Francisco Leon
Nov 27, 2010·Surgery Today·Takehisa Ueno, Masahiro Fukuzawa
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Oct 14, 2011·Mucosal Immunology·M SipsG Alter
Dec 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P L OhD F Mercer
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
Jan 22, 2013·Nature Immunology·Jochem H BerninkHergen Spits
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
May 24, 2013·Nature·Matthew R HepworthGregory F Sonnenberg
Apr 30, 2014·Blood·Mette D Hazenberg, Hergen Spits
May 14, 2014·International Immunology·Gregory F Sonnenberg
Sep 16, 2014·Immunity·Luc Van KaerDanyvid Olivares-Villagómez
Dec 19, 2014·Nature Immunology·Gérard EberlEric Vivier

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Citations

Sep 21, 2016·Current Gastroenterology Reports·Alexander KroemerThomas M Fishbein
Feb 18, 2017·Current Opinion in Organ Transplantation·Brenna HoulihanAlexander Kroemer
Nov 20, 2019·Immunity, Inflammation and Disease·Banu BatyrovaBenedict J Chambers
Feb 6, 2020·Viral Immunology·S Rameeza Allie, Troy D Randall
Feb 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali NazmiDanyvid Olivares-Villagómez
Apr 5, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Elena Gómez-MassaPaloma Talayero
Jul 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jiman KangAlexander Kroemer
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luc Van Kaer, Danyvid Olivares-Villagómez
Jan 8, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Elena Gómez-MassaEstela Paz-Artal
Jan 13, 2018·Digestive Diseases and Sciences·Augusto LauroIgnazio R Marino
Nov 4, 2017·Annual Review of Pathology·Eric Perkey, Ivan Maillard
Feb 20, 2020·International Journal of Molecular Sciences·Masutaka FurueTakeshi Nakahara

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