Innate Lymphoid Cells in the Airways: Their Functions and Regulators

Allergy, Asthma & Immunology Research
Keisuke OrimoHideaki Morita

Abstract

Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways-including structural cells and immune cells-interact to form a precise defense system against pathogens and antigens that involve both innate immunity and acquired immunity. Accumulating evidence suggests that innate lymphoid cells (ILCs) play critical roles in the maintenance of tissue homeostasis, defense against pathogens and the pathogenesis of inflammatory diseases, especially at body surface mucosal sites such as the airways. ILCs are activated mainly by cytokines, lipid mediators and neuropeptides that are produced by surrounding cells, and they produce large amounts of cytokines that result in inflammation. In addition, ILCs can change their phenotype in response to stimuli from surrounding cells, which enables them to respond promptly to microenvironmental changes. ILCs exhibit substantial heterogeneity, with different phenotypes and functions depending on the organ and type of inflammation, presumably because of differences in microenvironments. Thus, ILCs may be a sensitive detector of microenvironmental changes, and analysis of their phenotype and function at local sites may enable us to better u...Continue Reading

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Citations

Jan 22, 2021·Allergy, Asthma & Immunology Research·Lore PollarisJeroen A J Vanoirbeek
Sep 11, 2020·The Lancet. Respiratory Medicine·Mariëlle W Pijnenburg, Louise Fleming
Mar 23, 2021·JCI Insight·Laura M Cobb, Michael R Verneris
Apr 16, 2021·Journal of Leukocyte Biology·E Evonne JeanDe'Broski R Herbert

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
bronchoalveolar lavage
lavage
RNA-seq

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