Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes

Journal of Neuroimmunology
Judith BoffeyHugh J Willison

Abstract

In Guillain-Barré syndrome following Campylobacter enteritis, anti-lipopolysaccharide antibodies cross-react with neural gangliosides, thereby precipitating autoimmune neuropathy. We examined the properties of 15 murine anti-LPS/ganglioside mAbs specific for NeuAc(alpha2-8)NeuAc-Gal disialosyl epitopes. Many mAbs displayed features of an innate B cell origin including polyreactivity (13/15), hybridoma CD5 mRNA expression (5/15), predominance of IgM (9/15) or IgG3 (3/6) isotype, low affinity, and utilisation of unmutated VH and VL VDJ rearrangements. Antibody specificity resided in highly selective V gene usage, with 6/15 mAbs being encoded by the VH7183.3b gene. These data indicate that neuropathogenic antiganglioside autoantibodies can arise from the natural autoantibody repertoire.

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Citations

Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mei-Chi HsuIan C M Maclennan
Jul 28, 2015·Annals of the New York Academy of Sciences·Nely Rodriguez-ZhurbenkoAna Maria Hernandez
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Hugh J Willison
Apr 8, 2006·Journal of Neuroimmunology·Marijke EurelingsAndries C Bloem
Dec 1, 2009·Biochemical and Biophysical Research Communications·Yukinari KatoDarell D Bigner
Nov 1, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Willi K BornRebecca L O'Brien
Sep 15, 2007·Glycobiology·Kate TownsonHugh J Willison
Sep 7, 2007·International Journal of Cancer. Journal International Du Cancer·Tsutomu FujimuraSen-itiroh Hakomori
Jul 11, 2006·Expert Review of Vaccines·Barton F Haynes, David C Montefiori
Sep 13, 2019·PLoS Neglected Tropical Diseases·Ricardo Dias PortelaStella Maria Barrouin-Melo

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