Inner ear histopathology in patients treated with cis-platinum

The Laryngoscope
C G Wright, S D Schaefer

Abstract

Temporal bone histopathology was studied in five patients (aged 51-67) who received cis-diamminedichloroplatinum (DDP) chemotherapy for head and neck squamous cell carcinoma. In each case, sensorineural hearing loss occurred during the course of treatment and temporal bones were acquired 3-5 hours postmortem for anatomical study. Scanning electron microscopy revealed acute degenerative changes in cochlear hair cells that appeared to be the result of drug treatment. However, the presence of age-related degeneration made it difficult to unequivocally identify hair cell loss due solely to ototoxicity. In one patient, a decrement in vestibular function was observed during DDP treatment. Postmortem examination showed severe degeneration of the maculae and cristae which could be correlated with the absence of caloric response seen after chemotherapy.

Citations

Oct 16, 2008·Pharmacogenomics·Jan OldenburgTone Ikdahl
Jan 22, 2002·The Laryngoscope·R HinojosaD R Schramm
Jun 1, 1995·Pharmacology & Toxicology·R RaviL P Rybak
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S C Bellman
Jan 1, 1985·Archives of Oto-rhino-laryngology·K Böheim, E Bichler
Oct 22, 2003·Archives of Medical Research·René Toral-MartiñónMario Shkurovich-Zaslavsky
Jul 1, 1993·The Journal of Laryngology and Otology·M WakeR Mount
Jan 11, 2008·The Journal of Laryngology and Otology·R Ramírez-CamachoJ Nevado
Jan 1, 1987·Hearing Research·S E Barron, E A Daigneault
Jan 2, 2001·Acta Oto-laryngologica·G LaurellE Ferrary
Sep 1, 1987·Acta Oto-laryngologica·J Caston, L Doinel
Jan 1, 1989·Cancer Investigation·L GoldenZ Deeb
Sep 18, 1999·Scandinavian Audiology·A De LauretisD Passàli
Jan 1, 1986·Acta Oto-laryngologica·G Laurell, E Borg
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Helge Rask-AndersenRudolf Glueckert
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jochen SchachtLeonard P Rybak
Oct 7, 2004·Hearing Research·Maurizio PreviatiAlessandro Martini
Jan 1, 1993·International Journal of Pediatric Otorhinolaryngology·P G ZorowkaP Gutjahr
Feb 1, 1987·International Journal of Andrology·G LaurellD Bagger-Sjöbäck
Apr 23, 2014·International Journal of Audiology·A Rodríguez ValienteR Ramírez Camacho
Oct 25, 2016·Toxicology Letters·Yasumitsu TakimotoShoichi Shimada
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin R KnightEdward A Neuwelt
Oct 1, 2008·Acta Cirúrgica Brasileira·Camila C YassudaOmar Féres
Oct 11, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P W ChengK Kondo
Dec 31, 1997·The Annals of Otology, Rhinology, and Laryngology·M Suzuki, K Kaga
Apr 1, 1986·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·V G SchweitzerC Sheridan
May 20, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G C AllenM K Wax
Aug 4, 2018·American Journal of Audiology·Johnnie K BassThomas E Merchant
Oct 15, 1985·Cancer·S D SchaeferC G Wright
Jun 1, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kathleen C Y Sie, Susan J Norton
Mar 1, 1985·Acta Oto-laryngologica·J Marco-AlgarraJ Marco
Jan 1, 1990·Acta Oto-laryngologica. Supplementum·M J GleesonL G Johnsson
Nov 1, 1989·Medical Toxicology and Adverse Drug Experience·M Y Huang, J Schacht
Jan 1, 1990·Pediatric Hematology and Oncology·C BührerR Laszig
Aug 1, 1988·British Journal of Audiology·J P Griffin
Sep 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B W Blakley, S F Myers
Oct 16, 2018·Frontiers in Oncology·Pattarawadee PrayuenyongDavid M Baguley
Jun 8, 2000·Annals of the New York Academy of Sciences·H D Humes

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