PMID: 8968728Nov 1, 1996Paper

Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma

The Histochemical Journal
David A WalshT P Fan

Abstract

Angiogenesis is an essential component of wound healing and inflammation. In the rat subcutaneous sponge implantation model, angiogenesis can be enhanced by administration of the sensory neuropeptide, substance P. We have used quantitative in vitro receptor autoradiography and immunohistochemistry to investigate the development of endogenous neurovascular regulatory systems in the newly-formed granulation tissue of this model. The fraction of endothelial cells immunoreactive for proliferating cell nuclear antigen, endothelial fractional area, and 133Xe clearance were used as measures of endothelial proliferation, neovascularization, and blood flow, respectively. Endothelial proliferation occurred predominantly in tissues surrounding the sponge, and peaked before neovascularization of sponge stroma and the establishment of sponge blood flow. Substance P-containing sensory nerves and specific, high affinity substance P binding sites with characteristics of neurokinin receptors of the NK1 subclass, were localized to microvessels surrounding the sponge at all time points. Lower density substance P binding sites were localized to newly formed microvessels within the sponge stroma, progressively increasing in density from day 4 to da...Continue Reading

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Citations

Jul 26, 2002·Regulatory Peptides·R D P MachadoS P Andrade
Apr 21, 2007·Annals of the Rheumatic Diseases·Sunita SuriDavid A Walsh
Jun 20, 2001·Biological & Pharmaceutical Bulletin·I SakaguchiK Kaneda
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SinghP Rameshwar
Jan 5, 2001·Expert Opinion on Investigational Drugs·S Brunelleschi
Jun 12, 2012·Experimental Cell Research·Lara A MuffleyNicole S Gibran
Apr 30, 2015·British Journal of Clinical Pharmacology·David A WalshSara Kelly
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jérémy ChéretChristelle Le Gall-Ianotto
Aug 6, 2016·Journal of Pharmacological Sciences·Mitsuhiro GodaHiromu Kawasaki
May 12, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Miguel MuñozRafael Coveñas
Apr 7, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Juliana B MendesSilvia P Andrade
Aug 14, 2008·Current Opinion in Rheumatology·Sadaf Ashraf, David Andrew Walsh
Nov 26, 2010·Neurosurgery·Niyazi ÖztürkSerdar Tüzüner
Aug 31, 2019·Cancers·Miguel MuñozRafael Coveñas
Nov 14, 2019·Mini Reviews in Medicinal Chemistry·Miguel MuñozRafael Coveñas
May 30, 2012·Nature Reviews. Rheumatology·Paul I Mapp, David A Walsh
Mar 19, 2021·Bone Research·Yan HuJiacan Su
Mar 11, 2021·Journal of Vascular and Interventional Radiology : JVIR·Osman AhmedJ David Prologo

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