Innervation and secretory function of transplanted human submandibular salivary glands

Transplantation
G GeerlingGordon Proctor

Abstract

Free submandibular gland autotransplantation is used to treat absolute tear deficiency. Although disconnected from any peripheral innervation, most transplants show increasing secretion for years. We have evaluated the secretory activity and autonomic innervation of such transplants. Secretory activity of glands in response to parasympatholytics and parasympathomimetics was evaluated by Schirmer's test and Technetium scintigraphy. Submandibular gland tissue specimens taken before and after transplantation were examined histologically. Relative hypersecretion during the first postoperative week suddenly decreased but then slowly increased during the first postoperative year. Hypersecretion was significantly reduced by parasympatholytics while carbachol rapidly increased secretion. Histology of transplanted glandular tissue showed parenchymal atrophy. Cholinesterase-positive nerves were abundant and in a similar distribution to normal with scattered positive ganglion cells. Adrenergic axons were fewer than normal and irregularly distributed. Early hypersecretion may be due to release of neurotransmitters from degenerating terminal axons. This is followed by a period of minimal secretion during which hypersensitivity of acinar cel...Continue Reading

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Citations

Oct 26, 2013·International Journal of Oral Science·Xiao-Feng ShanGuang-Yan Yu
Apr 7, 2012·The Journal of Surgical Research·Ning-Yan YangGuang-Yan Yu
Mar 27, 2010·Neuroscience Letters·Konstantinos I TosiosAlexandra Sklavounou
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Feb 11, 2015·Journal of Molecular Pharmaceutics & Organic Process Research·Jia-Zeng SuGuang-Yan Yu
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Mar 13, 2014·Acta Histochemica Et Cytochemica·Taketo SusaToshiyuki Matsuzaki
Jul 2, 2020·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Akram Abdo AlmansooriJong-Ho Lee
Jan 11, 2014·Journal of Prosthodontic Research·Miho OgawaTakashi Tsuji

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