Innervation of burst firing spiny interneurons by pyramidal cells in deep layers of rat somatomotor cortex: paired intracellular recordings with biocytin filling

Neuroscience
J Deuchars, A M Thomson

Abstract

Intracellular recordings were obtained from a class of neuron defined electrophysiologically as burst firing interneurons in layers V and VI in slices of adult rat somatomotor cortex. Four of these cells were recovered histologically. These four cells had resting membrane potentials between -68 and -80 mV, a mean input resistance of 77 +/- 16.2 M omega (measured from the voltage deflection produced by a 100 ms, 0.5 nA hyperpolarizing pulse delivered from a membrane potential of -80 mV) and responded to injections of depolarizing current from membrane potentials negative of -70 to -75 mV with an initial burst of action potentials followed by a complex afterhyperpolarization. In response to injection of larger (0.5-1.5 nA) hyperpolarizing current pulses from membrane potentials between -60 and -70 mV, 15 of 20 burst firing cells (three of four recovered histologically) that were tested displayed delayed inward rectification, and in all 20 cells of this type, responses to large negative current pulses were followed by a rebound depolarization that could initiate action potentials. Filling of four of these cells with biocytin and subsequent histological processing revealed that they were bitufted with sparsely to medium spiny dendr...Continue Reading

References

Mar 15, 1991·The Journal of Comparative Neurology·B A McGuireT N Wiesel
Jun 22, 1990·The Journal of Comparative Neurology·Y Chagnac-AmitaiD A Prince
May 15, 1987·The Journal of Comparative Neurology·P L GabbottD Whitteridge
Jan 1, 1986·Experimental Brain Research·Z F KisvárdayP Somogyi
Mar 1, 1974·The Journal of Comparative Neurology·J E GrunerC Sotelo
Mar 1, 1994·Trends in Neurosciences·A M Thomson, J Deuchars

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Citations

Jun 1, 2000·Progress in Neurobiology·A M Thomson
Oct 6, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·A M Thomson
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Apr 21, 2009·Nature Reviews. Neuroscience·Tiago Branco, Kevin Staras
Apr 24, 1999·The European Journal of Neuroscience·A B AliA M Thomson
Mar 11, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alex M ThomsonOliver T Morris
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyong MaAriel Agmon
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giorgio A AscoliMichele Migliore
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Antoine BrémaudAlex M Thomson
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A Castro-Alamancos, B W Connors
Apr 20, 2010·Brain Research Reviews·Alex M Thomson, William E Armstrong
Oct 27, 2009·Progress in Neurobiology·Steven R Vincent
Sep 11, 2012·Neuron·Julia J HarrisDavid Attwell
May 5, 2016·Journal of Neuroscience Methods·Ricardo A ValenzuelaDaniel V Madison
Jul 6, 2016·Trends in Neurosciences·Andrew J Trevelyan
Nov 13, 2004·The Journal of Physiology·Jo Watts, Alex M Thomson
May 19, 2006·Journal of Neurophysiology·Brian HalabiskyDavid A Prince
Jun 4, 2019·Frontiers in Synaptic Neuroscience·Jean-Sébastien Jouhanneau, James F A Poulet
Oct 12, 2017·Frontiers in Neuroanatomy·Audrey Mercer, Alex M Thomson
Dec 9, 1996·The Journal of Comparative Neurology·F M Zhou, J J Hablitz
Jul 28, 2021·Neuropharmacology·Jonathan LezmyDavid Attwell
Jan 10, 1997·Science·A M Thomson

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