Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study

Journal of Neuroscience Research
X NavarroW R Kennedy

Abstract

The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-related peptide, and protein zero. The antibodies were localized using cyanine 3.18 labeled anti-rabbit gamma globulin. PGP 9.5 immunolocalization showed dense nerve bundles at the base of the foot pad with branches to larger blood vessels, sweat glands and epidermis. Sweat gland tubules were surrounded by numerous sudomotor axons; single fibers accompanied the sweat duct toward the skin's surface. Nerve bundles containing myelinated and unmyelinated axons ran through and around the centrally located sweat gland cluster to end in free nerve endings and Meissner's-like corpuscles at the apex of the foot pad. Other bundles running parallel to the epidermis gave arcuate branches that supplied epidermis on the sides of the pads with a rich nerve network, principally with free nerve endings that often reached the most superficial cell layers of epidermis. Calcitonin gene-related peptide-immunoreactive (-ir) nerves were distr...Continue Reading

References

Dec 1, 1978·Acta Physiologica Scandinavica·J M LundbergS Said
Jul 1, 1990·Cell and Tissue Research·L WangO Johansson
Nov 1, 1990·Journal of the Autonomic Nervous System·X Navarro, W R Kennedy
Jan 3, 1985·Nature·S D BrainI MacIntyre
Nov 14, 1983·Brain Research·R J ThompsonJ Rode
Jan 1, 1993·Journal of the Neurological Sciences·X NavarroE Goñalons
Apr 1, 1993·Journal of the Neurological Sciences·W R Kennedy, G Wendelschafer-Crabb

❮ Previous
Next ❯

Citations

Aug 7, 2009·Cell and Tissue Research·Moe TsutsumiMitsuhiro Denda
Oct 7, 2000·Autonomic Neuroscience : Basic & Clinical·G Guidry, S C Landis
Mar 2, 2002·Autonomic Neuroscience : Basic & Clinical·Jorge J VilchesXavier Navarro
Jan 30, 2002·British Journal of Pharmacology·Andrew D GrantSusan D Brain
Jul 31, 2001·Experimental Neurology·Y W LinS T Hsieh
Oct 3, 2008·The Journal of Investigative Dermatology·Moe TsutsumiMitsuhiro Denda
Mar 16, 2016·Journal of Neuroscience Methods·Folabomi A OladosuAndrea G Nackley
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaGuido Cavaletti
Jun 29, 2007·The European Journal of Neuroscience·Lauriane UlmannRémy Schlichter
May 23, 2007·Basic & Clinical Pharmacology & Toxicology·Jiyu TianJingchun Wang
Aug 25, 2010·Journal of Neurochemistry·Mohammad R KhazaeiPeter Young
Oct 19, 2011·Journal of the Peripheral Nervous System : JPNS·Jordi BrunaEsther Udina
Dec 16, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Eduardo Martínez-MartínezGabriel Gutiérrez-Ospina
Jan 6, 1999·Experimental Neurology·H Y ChiangS T Hsieh
Feb 18, 2016·Journal of the Peripheral Nervous System : JPNS·Miguel A RubioXavier Navarro
Jun 16, 2012·Neuropeptides·Jorge J VilchesXavier Navarro
Jul 6, 2004·Molecular and Cellular Neurosciences·Päivi H Hiltunen, Matti S Airaksinen
Dec 16, 2016·Advanced Healthcare Materials·Daniel SantosJaume Del Valle
Jun 25, 2017·Experimental Neurology·Jon P NiemiRichard E Zigmond
Jan 20, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D GuinardR Saxod
Apr 7, 1997·The Journal of Comparative Neurology·X NavarroW R Kennedy
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
Mar 15, 2011·The European Journal of Neuroscience·Gary J BennettChiang Siau
Apr 12, 2000·Journal of Neuropathology and Experimental Neurology·S T HsiehW M Lin
Aug 20, 2020·Nature Reviews. Immunology·Maya SchillerAsya Rolls

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.