PMID: 9541477Apr 16, 1998Paper

Innervation of developing human taste buds. An immunohistochemical study

Histochemistry and Cell Biology
M Witt, K Reutter

Abstract

Morphological changes in developing human gustatory papillae during the 6th to the 23rd postovulatory week have been studied. The general innervation pattern of taste papillae and taste bud primordia was revealed immunohistochemically using antibodies against protein gene product 9.5 (PGP9.5), neurofilament H (NFH), neurofilament L (NFL), neurone-specific enolase (NSE), and tubulin. The autonomic and somatosensory nerve supply has been investigated using antibodies against substance P (SP), calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH), neuropeptide Y (NPY), the neuronal form of nitric oxide synthase (n-NOS), and, enzyme histochemically, NADPH-diaphorase. Nerve fibers approach the basal membrane of the lingual epithelium around the 7th postovulatory week and invade the epithelium of papilla-like structures at the 8th week, but some also penetrate the basal membrane of the non-papillary epithelium. They are in close contact with slender epithelial cells that are considered to be the taste bud's progenitor cells. Early human taste buds situated at the anterior part of the tongue do not necessarily require a dermal (later fungiform) papilla. The NADPH-diaphorase reaction revealed positive results in dermal nerv...Continue Reading

Citations

Apr 11, 2006·Histochemistry and Cell Biology·Donald GanchrowEve Arki-Burstyn
Oct 12, 2005·Journal of Neurocytology·Bruce Oakley, Martin Witt
Apr 25, 2000·Brain Research. Brain Research Protocols·J Morris-WimanR Sego
Dec 22, 2015·Journal of Chemical Neuroanatomy·Ahmed RashwanHiroshi Kiyama
Jan 24, 2003·The Journal of Comparative Neurology·Joseph-Pascal Mbiene, John David Roberts
Mar 31, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Ashraf El-SharabySatoshi Wakisaka
Feb 27, 2008·The Journal of Comparative Neurology·Brian GulbransenThomas E Finger
Feb 18, 2012·Anatomia, histologia, embryologia·E Marettová, M Maretta
May 25, 2005·Pain·Giuseppe LauriaPierluigi Sapelli
Mar 29, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anne HansenEckart Zeiske
Jun 17, 2010·The Clinical Journal of Pain·Paola PenzaGiuseppe Lauria
May 4, 2017·Psychonomic Bulletin & Review·Vanessa AndréVirginie Durier
Jun 16, 2000·Physiology & Behavior·J R Ganchrow

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