PMID: 6164439Apr 6, 1981Paper

Innervation of embryonic hippocampal implants by regene-rating axons of cholinergic septal neurons in the adult rat

Brain Research
L F KromerU Stenevi

Abstract

The regeneration of the septal cholinergic system in adult rats has been studied in animals bearing transplants of hippocampus taken from 20-40 mm rat fetuses (approximately 17-21 days of gestation). The septal axons located within the fimbria and the dorsal fornix were lesioned and a cavity was prepared at the rostral end of the hippocampus. The embryonic tissue was placed adjacent to the severed end of the fornix-fimbria. The time-course of ingrowth of cholinergic fibers into the transplant was monitored by acetylcholine esterase (AChE) histochemistry and the determination of the levels of choline acetyltransferase (ChAT). Both methods indicate that there is a progressive ingrowth into the transplant of cholinergic fibers up to 3 months after transplantation. The newly-formed AChE-positive fibers in the transplant remain beyond one year after transplantation and are thus presumably permanent. Both horseradish peroxidase (HRP) injections into the implant and radiofrequency lesions of the septal-diagonal band area indicate that the principal source of these fibers is the AChE-positive neurons of the medial septum and the nucleus of the diagonal band which normally form the septohippocampal cholinergic projection. The results su...Continue Reading

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Citations

Jul 19, 1991·Brain Research·G BuzsákiF H Gage
May 1, 1990·Journal of Neuroscience Methods·C T Montgomery, J A Robson
Nov 1, 1983·Brain Research·P J ReierL Guth
Jan 1, 1987·Brain Research·M A SharkeyR M Dom
Jan 1, 1996·Behavioural Brain Research·B J TarriconeW C Low
Jan 1, 1984·Progress in Neurobiology·J C de la Torre
Aug 1, 1983·Neuroscience·G Raisman, F F Ebner
Jan 1, 1994·Neuroscience·R R de la CruzJ M Delgado-García
Mar 1, 1987·Brain Research Bulletin·E B Ezerman, L F Kromer
Jan 31, 1991·Behavioural Brain Research·L A Rothblat, L F Kromer
Dec 1, 1996·Progress in Neurobiology·A K Shetty, D A Turner
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L F Kromer, C J Cornbrooks
Dec 1, 1988·Journal of Neurosurgery·T J MampalamF R Sharp
Jan 1, 1982·Annals of the New York Academy of Sciences·E Roberts
Jan 1, 1987·Annals of the New York Academy of Sciences·D G Stein, E J Mufson

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