PMID: 7540955Apr 1, 1995Paper

Innervation of human epicardial coronary veins: immunohistochemistry and vasomotility

Cardiovascular Research
O Saetrum OpgaardL Edvinsson

Abstract

The aim was to investigate the innervation and vasomotor responses to classical and putative transmitters of the coronary venous bed. The innervation of human epicardial coronary veins was investigated using acetylcholinesterase histochemistry and immunofluorescence staining, together with antisera against the general neuronal marker protein gene product 9.5 (PGP 9.5), the catecholamine synthesising enzyme tyrosine hydroxylase, and neuropeptides [neuropeptide Y, vasoactive intestinal peptide (VIP), substance P, and calcitonin gene related peptide (CGRP)]. The vasomotor responses to noradrenaline, acetylcholine, neuropeptide Y, substance P, human alpha calcitonin gene related peptide (alpha CGRP), and VIP were tested on isolated circular human epicardial coronary vein segments. A network of nerve fibres was shown in the major epicardial coronary veins by means of an antiserum to PGP 9.5. The majority of the perivascular nerve fibres possessed neuropeptide Y and tyrosine hydroxylase immunoreactivity. Only a few nerve fibres displayed substance P, CGRP, and VIP immunoreactivity and acetylcholinesterase activity. Noradrenaline and acetylcholine induced powerful contractions of all the tested segments, whereas no contraction was ind...Continue Reading

Citations

Jun 14, 2000·European Journal of Pharmacology·O Saetrum OpgaardL Edvinsson
Dec 23, 1999·European Journal of Pharmacology·O Saetrum OpgaardP R Saxena
Apr 1, 1996·Pharmacology & Toxicology·O Saetrum Opgaard, L Edvinsson
Jan 29, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hakima MechichePhilippe Devillier
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

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