Innervation territories of single sympathetic C fibers in human skin

Journal of Neurophysiology
M SchmelzH O Handwerker

Abstract

Microneurography techniques were used to record action potentials from unmyelinated nerve fibers (C fibers) in the cutaneous fascicles of the peroneal nerve in healthy volunteers. C units were identified by their long latency responses to electrical stimulation of their terminals in the skin. Their responsiveness to mechanical or heat stimuli applied to the skin or to sympathetic reflex provocation tests was determined by transient slowing of conduction velocity following activation (marking technique). In a sample of 381 C units, 59 were unresponsive to mechanical and thermal stimulation of their endings, but responded to sympathetic reflex provocation tests, e.g., arousal or deep inspiration. They were classified as sympathetic efferent units. On average, conduction velocities of sympathetic units were lower (0.78 +/- 0.12 m/s, mean +/- SD) than those of mechano-heat (CMH) or mechanoresponsive (CM) afferent C units (0.91 +/- 0.14 m/s). Endings of most of the sympathetic units were located in the skin of toes or in the foot dorsum. Innervation territories of 16 sympathetic units were mapped by means of conditioning transcutaneous electrical stimuli. Twelve units had one continuous skin territory, whereas two units had two and ...Continue Reading

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Citations

Feb 26, 2019·Pain Reports·Julia ForstenpointnerRalf Baron
Dec 25, 2003·Muscle & Nerve·Masahide KondoShigeki Kuzuhara
Jul 12, 2002·Annals of Neurology·Frank BirkleinFrank Erbguth
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Feb 22, 2018·Journal of Neurophysiology·Jan TodeWilfrid Jänig
Mar 4, 2003·Journal of Neurophysiology·M SchmelzH O Handwerker

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