Innovation in the imaging perianal fistula: a step towards personalised medicine

Therapeutic Advances in Gastroenterology
Kapil SahnanPhillip F C Lung

Abstract

Perianal fistula is a topic both hard to understand and to teach. The key to understanding the treatment options and the likely success is deciphering the exact morphology of the tract(s) and the amount of sphincter involved. Our aim was to explore alternative platforms better to understand complex perianal fistulas through three-dimensional (3D) imaging and reconstruction. Digital imaging and communications in medicine images of spectral attenuated inversion recovery magnetic resonance imaging (MRI) sequences were imported onto validated open-source segmentation software. A specialist consultant gastrointestinal radiologist performed segmentation of the fistula, internal and external sphincter. Segmented files were exported as stereolithography files. Cura (Ultimaker Cura 3.0.4) was used to prepare the files for printing on an Ultimaker 3 Extended 3D printer. Animations were created in collaboration with Touch Surgery™. Three examples of 3D printed models demonstrating complex perianal fistula were created. The anatomical components are displayed in different colours: red: fistula tract; green: external anal sphincter and levator plate; blue: internal anal sphincter and rectum. One of the models was created to be split in half...Continue Reading

References

Sep 1, 1978·Journal of the Royal Society of Medicine·L E Hughes
Jan 12, 2001·Radiology·R G Beets-TanJ M van Engelshoven
Nov 30, 2002·Lancet·Gordon BuchananClive I Bartram
Mar 15, 2006·Gastroenterology·Laurent BeaugerieJacques Cosnes
Aug 29, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Ardizzone, G Bianchi Porro
Apr 8, 2011·Diseases of the Colon and Rectum·Srihari MahadevMichael J Solomon
Sep 24, 2013·IEEE Transactions on Medical Imaging·Dwarikanath MahapatraJoachim M Buhmann
May 14, 2014·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Patrick Eniola Fadero, Mahir Shah
Jun 22, 2014·Gut·Krisztina B GecseUNKNOWN World Gastroenterology Organization International Organisation for Inflammatory Bowel Diseases IOIBD European Society of Col
Jun 28, 2016·Seminars in Ultrasound, CT, and MR·Damian J M Tolan
Feb 18, 2017·Radiological Physics and Technology·Bram van Ginneken
Feb 23, 2017·BMJ : British Medical Journal·Kapil SahnanRobin Ks Phillips
Mar 10, 2017·Journal of Digital Imaging·Hyunkwang LeeSynho Do
Jul 29, 2017·International Journal of Pharmaceutics·Alvaro GoyanesMine Orlu
Jan 23, 2018·BMJ Simulation & Technology Enhanced Learning·Justine GarciaKevin Lachapelle

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Citations

Nov 21, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S H Emile, S D Wexner
Oct 13, 2019·Surgical Endoscopy·Andrea PietrabissaFerdinando Auricchio
Feb 7, 2020·Annals of Saudi Medicine·Khawaja Bilal WaheedZechriah Jebakumar Arulanatham
May 22, 2019·Current Drug Targets·Kapil SahnanJanindra Warusavitarne
Mar 4, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jonathan DuckettAswini Balachandran
Mar 17, 2020·Techniques in Coloproctology·G PellinoUNKNOWN Italian Society of Colorectal Surgery SICCR
Nov 22, 2020·Health and Quality of Life Outcomes·Samuel O AdegbolaAilsa L Hart
Apr 6, 2021·Clinics in Colon and Rectal Surgery·Deborah S KellerRoel Hompes

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