Innovations in Instrumentation for Positron Emission Tomography

Seminars in Nuclear Medicine
Eric Berg, Simon R Cherry

Abstract

PET scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the 3-dimensional distribution of radiotracers inside the body. PET scanners are commonly integrated with x-ray CT or MRI scanners in hybrid devices that can provide both molecular imaging (PET) and anatomical imaging (CT or MRI). Despite decades of development, significant opportunities still exist to make major improvements in the performance of PET systems for a variety of clinical and research tasks. These opportunities stem from new ideas and concepts, as well as a range of enabling technologies and methodologies. In this paper, we review current state of the art in PET instrumentation, detectors and systems, describe the major limitations in PET as currently practiced, and offer our own personal insights into some of the recent and emerging technological innovations that we believe will impact the field. Our focus is on the technical aspects of PET imaging, specifically detectors and system design, and the opportunity and necessity to move closer to PET systems for diagnostic patient use and in vivo biomedical research that truly approach the physical performance limits while remaining mindful...Continue Reading

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Citations

Apr 24, 2019·Physics in Medicine and Biology·Peng PengSimon R Cherry
Sep 19, 2019·Physics in Medicine and Biology·Mohammadreza Teimoorisichani, Andrew L Goertzen
Aug 16, 2019·Physics in Medicine and Biology·Mariele StockhoffStefaan Vandenberghe
Jul 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Dimitris VisvikisMathieu Hatt
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Jul 25, 2019·Scientific Reports·Gabriel Reynés-LlompartCristina Gámez-Cenzano
Jun 27, 2019·Physics in Medicine and Biology·Jianfeng XuQiyu Peng
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Dec 29, 2020·European Journal of Medicinal Chemistry·Shufeng LiHaiwei Xu
Jan 30, 2021·Seminars in Nuclear Medicine·Mathieu HattDimitris Visvikis
Mar 13, 2021·Physics in Medicine and Biology·Chunhui ZhangZheng Liu
Mar 5, 2021·Physics in Medicine and Biology·Milan DecuyperRoel Van Holen
Mar 13, 2021·Physics in Medicine and Biology·Dennis R Schaart
Mar 27, 2021·Physics in Medicine and Biology·Abhijit J Chaudhari, Ramsey D Badawi
Sep 5, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mathieu HattDimitris Visvikis
Jul 11, 2021·Seminars in Nuclear Medicine·Yu-Jung Tsai, Chi Liu
Jul 15, 2021·Physics in Medicine and Biology·Mariele StockhoffStefaan Vandenberghe
Oct 15, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Vanessa NadigVolkmar Schulz
Jul 30, 2020·Advanced Drug Delivery Reviews·Carlos Pérez-MedinaRoy van der Meel

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