Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging

Seminars in Nuclear Medicine
Ryo TamuraJan Grimm

Abstract

Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy. Cerenkov Luminescence Imaging (CLI) utilizes CL generated from clinically relevant radionuclides alongside optical imaging instrumentation. CLI is advantageous over traditional nuclear imaging methods in terms of infrastructure cost, resolution, and imaging time. Furthermore, CLI is a truly multimodal imaging method where the same agent can be detected by two independent modalities, with optical (CL) imaging and with positron emission tomography (PET) imaging. CL has been combined with small molecules, biomolecules and nanoparticles to improve diagnosis and therapy in cancer research. Here, we cover the fundamental breakthroughs and recent advances in reagents and instrumentation methods for CLI as ...Continue Reading

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Citations

Jul 18, 2019·Journal of Biomedical Optics·Nallely Jiménez-MancillaHéctor Mendoza-Nava
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Darpan N PandyaThaddeus J Wadas
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May 1, 2021·International Journal of Molecular Sciences·Zsombor RitterErzsébet Schmidt
Aug 9, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giacomo PirovanoThomas Reiner

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