PMID: 9192063Mar 1, 1997Paper

Innovations in topical therapy

Baillière's Clinical Gastroenterology
F Richter, W Scheppach

Abstract

Topical therapy can be considered the standard treatment for distal ulcerative colitis. The group of drugs of first choice are the aminosalicylates which are effective in inducing remission in acute disease as well as in preventing relapse. Corticosteroids appear to be slightly less effective and have no proven benefit in maintenance therapy. With new topical steroids, such as budesonide, systemic effects can be minimized. The major role of corticosteroids is to complement aminosalicylates, when necessary. The new topical compounds appear to be especially valuable when there is a long-term requirement for corticosteroids. With the vast majority of patients obtaining remission with standard treatment, it is difficult to make the case for alternative substances. Short-chain fatty acids, local anaesthetics and bismuth compounds seem to be the most promising innovations in topical therapy although their equivalence or even superiority to mesalazine has not been established.

References

Dec 1, 1992·Digestive Diseases and Sciences·M CampieriL Barbara
Jan 1, 1992·Scandinavian Journal of Gastroenterology·A DanielssonR Willén
Jan 1, 1990·The Medical Clinics of North America·L R Sutherland
Jul 11, 1990·Gastroenterology·W L Biddle, P B Miner
Feb 1, 1991·Digestive Diseases and Sciences·R I BreuerR Caprilli
Aug 1, 1990·Alimentary Pharmacology & Therapeutics·S D RyderJ M Rhodes
Jan 1, 1990·Diseases of the Colon and Rectum·R KochharF Patel
Nov 1, 1989·Scandinavian Journal of Gastroenterology·S BjörckH Ahlman
Jan 5, 1989·The New England Journal of Medicine·J M HarigC M Wood
Aug 1, 1988·Journal of Clinical Gastroenterology·M CampieriL Barbara
Feb 1, 1986·Diseases of the Colon and Rectum·M CampieriS Boschi
Feb 1, 1986·Digestive Diseases and Sciences·M JayD R Antonow
May 16, 1981·British Medical Journal·K R PalmerC D Holdsworth
Jun 1, 1995·Alimentary Pharmacology & Therapeutics·J K Marshall, E J Irvine
Jun 1, 1995·Alimentary Pharmacology & Therapeutics·P VerniaA Torsoli
Dec 1, 1994·Alimentary Pharmacology & Therapeutics·S TarpilaE Toivanen
Dec 1, 1994·Alimentary Pharmacology & Therapeutics·R LöfbergJ F Møller-Petersen
Oct 1, 1993·Alimentary Pharmacology & Therapeutics·A E JarløvR M Bech
Apr 1, 1993·Alimentary Pharmacology & Therapeutics·C J Mulder, G N Tytgat
Oct 1, 1995·Alimentary Pharmacology & Therapeutics·M LémannR Modigliani
Jun 1, 1996·European Journal of Gastroenterology & Hepatology·R Löfberg

❮ Previous
Next ❯

Citations

Jul 16, 2002·Gut·S B Hanauer
Nov 24, 2004·Advanced Drug Delivery Reviews·Ulrich Klotz, Matthias Schwab
Jun 5, 2004·Gastroenterology Clinics of North America·Jeffry A Katz
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·G FalascoAlastair Forbes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.