PMID: 9425668Jan 13, 1998Paper

Innovative approaches to novel antibacterial drug discovery

Current Opinion in Biotechnology
J Trias, E M Gordon

Abstract

Increasing antibiotic resistance in microorganisms and new emerging pathogens have become a major problem in our society. Rising to satisfy this urgent medical need is a recent confluence of powerful new drug discovery technologies: combinatorial chemistry; sequence and functional genomic analysis; and novel methods of high-throughput screening. The combination of these technologies will bring to bear untapped power in the search for new antimicrobials.

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Jul 21, 1999·Journal of Biotechnology·S KreitlowU Lindequist
Jul 11, 2001·Drug Discovery Today·D J. ChristensenP T. Hamilton
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Nov 5, 1999·Applied and Environmental Microbiology·A A Bianchi, F Baneyx
Aug 28, 1999·Journal of Medicinal Chemistry·M J SofiaH R Axelrod

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