Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats

Dental Research Journal
Sohrab AsefiAli Lotfi

Abstract

Curcumin is the most active compound in turmeric. It can suppress the nuclear factor kappa-light-chain-enhancer of activated B cells pathway and prevent the osteoclastogenesis procedure. This study aimed to be the first to evaluate the effect of curcumin on the rate of orthodontic tooth movement (OTM). Forty rats were used as follows in each group: (1) negative control: Did not receive any appliance or injection; (2) positive control: received 0.03 cc normal saline and appliance; (3) gelatin plus curcumin (G): Received 0.03 cc hydrogel and appliance; and (4) chitosan plus curcumin (Ch): Received 0.03 cc hydrogel and appliance. They were anesthetized and closed nickel-titanium coil springs were installed between the first molars and central incisors unilaterally as the orthodontic appliance. After 21 days, the rats were decapitated, and the distance between the first and second molars was measured by a leaf gauge. Howship's lacunae, blood vessels, osteoclast-like cells, and root resorption lacunae were evaluated in the histological analysis. Data were analyzed by one-way ANOVA, Tukey's test, and t-test (P < 0.05 consider significant). No significant difference was found in OTM between groups delivered orthodontic forces. Curcumi...Continue Reading

References

Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal

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Citations

Jul 25, 2020·BMC Complementary Medicine and Therapies·Zhengeng LiangYu Wang

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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