Innovative health risk assessment of heavy metals in Chinese herbal medicines based on extensive data.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Tian-Tian ZuoShuang-Cheng Ma

Abstract

In the present study, the concentrations of lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and copper (Cu) in 2245 batches of Chinese herbal medicines (CHMs) were measured using inductively coupled plasma-mass spectroscopy (ICP-MS). We developed a risk assessment strategy that assessed the heavy metal-associated health risk of CHMs based on our large dataset. Using a combination of the mean and 95th percentile (P95) values of the chronic daily intake (CDI), hazard quotient (HQ), hazard index (HI), and lifetime cancer risk (CR), the health risks of the average exposure population and the high exposure population were estimated, respectively. To obtain a precise and realistic risk assessment, the exposure frequency and exposure duration were determined using questionnaire data from 20,917 randomly selected volunteers. Additionally, given the specific ingestion characteristics of CHMs, the safety factor and the transfer rates of heavy metals were highlighted as well. The concentrations of Pb, Cd, As, Hg, and Cu in 2245 batches of CHMs were 1.566, 0.299, 0.391, 0.074, and 8.386 mg/kg, respectively. The mean HI values indicated that consumption of most CHMs would not pose an unacceptable health risk to the average exposure pop...Continue Reading

Citations

Jan 31, 2021·Journal of Hazardous Materials·Chih-Min YangChao-Hsiang Chen
Aug 21, 2021·Chinese Medicine·Xiaoting ZhengGing Chan
Aug 21, 2021·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Kai QiuGang Wu
Dec 4, 2021·Environmental Science and Pollution Research International·Tian-Tian ZuoLang-Chong He

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