Innovative strategies to treat skin wounds with mangiferin: fabrication of transfersomes modified with glycols and mucin.

Nanomedicine
Mohamad AllawMaria Manconi

Abstract

Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.

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Citations

Jun 25, 2021·Advanced Drug Delivery Reviews·Matthias MarczynskiOliver Lieleg
Oct 29, 2021·Nanomedicine·Pablo OyarzúnFrancisco Arriagada

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Methods Mentioned

BETA
transmission electron microscopy
Dynamic Light Scattering
biopsies

Software Mentioned

XLStatistics

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