Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

Frontiers in Microbiology
Rita M PintoPatrick Van Dijck

Abstract

Bacterial biofilms represent a major concern at a worldwide level due to the high demand for implantable medical devices and the rising numbers of bacterial resistance. The complex structure of the extracellular polymeric substances (EPS) matrix plays a major role in this phenomenon, since it protects bacteria from antibiotics, avoiding drug penetration at bactericidal concentrations. Besides, this structure promotes bacterial cells to adopt a dormant lifestyle, becoming less susceptible to antibacterial agents. Currently, the available treatment for biofilm-related infections consists in the administration of conventional antibiotics at high doses for a long-term period. However, this treatment lacks efficiency against mature biofilms and for implant-associated biofilms it may be necessary to remove the medical device. Thus, biofilm-related infections represent an economical burden for the healthcare systems. New strategies focusing on the matrix are being highlighted as alternative therapies to eradicate biofilms. Here, we outline reported matrix disruptive agents, nanocarriers, and technologies, such as application of magnetic fields, photodynamic therapy, and ultrasounds, that have been under investigation to disrupt the EP...Continue Reading

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Citations

Sep 11, 2020·International Journal of Microbiology·Gedif Meseret Abebe
Mar 7, 2021·Microorganisms·Katrien Van DyckPatrick Van Dijck
Mar 18, 2021·International Journal of Nanomedicine·Henry DevlinEoin Casey
Mar 27, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Matthias Militz, Martin Ellenrieder
Apr 1, 2021·Biotechnology Advances·Maria Del Mar Cendra, Eduard Torrents
Aug 10, 2021·Chemical Communications : Chem Comm·Patricia BondiaJoaquim Torra
Dec 1, 2021·Journal of Applied Microbiology·Eleni AsimakopoulouAlexandros Ch Stratakos
Nov 23, 2021·Angewandte Chemie·Sorour DarvishiIoanna Mela
Jan 21, 2022·International Journal of Antimicrobial Agents·Arianna PaniFrancesco Scaglione

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Methods Mentioned

BETA
gene modification
scanning electron microscopy
fluorescence microscopy

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