PMID: 15332590Aug 31, 2004Paper

Innovative tissue engineering structures through advanced manufacturing technologies

Journal of Materials Science. Materials in Medicine
Gianluca CiardelliPaolo Giusti

Abstract

Awide range of rapid prototyping (RP) techniques for the construction of three-dimensional (3-D) scaffolds for tissue engineering has been recently developed. In this study, we report and compare two methods for the fabrication of poly-(epsilon-caprolactone) and poly-(epsilon-caprolactone)-poly-(oxyethylene)-poly-(epsilon-caprolactone) copolymer scaffolds. The first technique is based on the use of a microsyringe and a computer-controlled three-axis micropositioner, which regulates motor speed and position. Polymer solutions are extruded through the needle of the microsyringe by the application of a constant pressure of 10-300 mm Hg, resulting in controlled polymer deposition of 5-600 microm lateral dimensions. The second method utilises the heating energy of a laser beam to sinter polymer microparticles according to computer-guided geometries. Materials may be fed either as dry powder or slurry of microparticles. Both powder granulometry and laser working parameters influence resolution (generally 300 microm x 700 microm), accuracy of sintering and surface and bulk properties of the final structures. The two RP methods allow the fabrication of 3-D scaffolds with a controlled architecture, providing a powerful means to study ce...Continue Reading

Citations

Jul 11, 2007·Journal of Materials Science. Materials in Medicine·H S RamanathK D Shah
Dec 7, 2011·Journal of Materials Science. Materials in Medicine·Caterina CristalliniGiulio D Guerra
Jul 9, 2005·Nature Materials·Scott J Hollister
Dec 18, 2013·Tissue Engineering. Part B, Reviews·Carlos Filipe C JoãoJoão Paulo Borges
Jul 31, 2014·Biotechnology and Bioengineering·Silvia ScaglioneRodolfo Quarto
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·G A SilvaR L Reis
Dec 24, 2005·Macromolecular Bioscience·Gianluca Ciardelli, Valeria Chiono
Jul 1, 2006·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M M Savalani, R A Harris
Jul 12, 2005·Biomacromolecules·Gianluca CiardelliPaolo Giusti

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