Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac).

Journal of Drug Targeting
Jafar AkbariAli Nokhodchi

Abstract

The purpose of this research was to enhance the transdermal delivery of diclofenac sodium niosomal formulations. To characterise the obtained niosomes, SEM, XRPD, DSC and ATR-FTIR were employed. The size of the niosomes increased from 158.00 ± 6.17 to 400.87 ± 4.99 nm when cholesterol was incorporated into the formulations. It was observed that the zeta potential of niofenac varies from -25.40 ± 1.352 to -43.13 ± 1.171 mV when the cholesterol percentage decreased from 2% to 0.2%. The higher entrapment efficiency percentage (63.70 ± 0.18%) was obtained for the formulations with larger particle sizes and higher cholesterol content. The optimised niofenac formulation showed a controlled release fashion where 61.71 ± 0.59% of the drug released within 24 h. The results showed that the value of permeated diclofenac sodium through the skin layers was higher for the niofenac gel formulation (242.3 ± 31.11 µg/cm2) compared to simple gel formulation (127.40 ± 27.80 µg/cm2). Besides, niofenac formulation outperformed the anti-inflammatory activities in the formalin test compared to the control and diclofenac simple gel group. The licking time was significantly lower in both early (40.2 ± 7.3 s) and late stages (432.4 ± 31.7 s) for niofena...Continue Reading

References

Jul 1, 1990·The Journal of Pharmacy and Pharmacology·J Príborský, E Mühlbachová
Dec 1, 1985·The Journal of Pharmacy and Pharmacology·A J BaillieA Rogerson
Sep 2, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·B VoraN K Jain
Mar 16, 2001·International Journal of Pharmaceutics·F P SchmookA Billich
Nov 13, 2003·Drug Delivery·Jaleh VarshosazAbdolhossein Rouholamini Najafabadi
Jul 12, 2005·International Journal of Pharmaceutics·Behrooz Nasseri
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Gamal M M El MaghrabyBrian W Barry
Dec 19, 2006·International Journal of Pharmaceutics·A NokhodchiT Ghafourian
Sep 25, 2007·Advanced Drug Delivery Reviews·Biana Godin, Elka Touitou
Jan 29, 2008·Lasers in Surgery and Medicine·Clara GómezDolores Blanco
Jun 26, 2008·International Journal of Pharmaceutics·Mahmoud MokhtarNagia A Megrab
Aug 8, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Ketan PancholiMohan Edirisinghe
Oct 21, 2009·Journal of Clinical Pharmacology·Jean-Luc KienzlerFabrice Nollevaux
Aug 5, 2010·Journal of Microencapsulation·Esmaeil MoazeniHossein Jamalifar
Sep 6, 2012·Advances in Colloid and Interface Science·N B MahaleS R Chaudhari
Aug 13, 2013·BioMed Research International·Saeed Ghanbarzadeh, Sanam Arami
Nov 26, 2013·Current Drug Delivery·Sandipan DasguptaBhaskar Mazumder
Jan 10, 2014·Drug Delivery·Saeed GhanbarzadehSanam Arami
Jan 28, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M BragagniP Mura
Oct 28, 2014·Journal of Applied Toxicology : JAT·Eui Chang Jung, Howard I Maibach
Jan 23, 2015·AAPS PharmSciTech·Rathapon AsasutjaritGarnpimol C Ritthidej
Aug 27, 2015·International Journal of Pharmaceutics·Giuseppina IoeleRita Muzzalupo
Sep 24, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Hossein Ali EbrahimiMohammad Barzegar Jalali
Jun 12, 2016·Colloids and Surfaces. B, Biointerfaces·Jafar AkbariAli Nokhodchi
Sep 3, 2016·Pharmaceutics·Rajan RajabalayaSheba R David
Sep 9, 2016·AAPS PharmSciTech·Muhammad Imran KhanLeena Peltonen
Sep 28, 2017·Pharmaceutical Nanotechnology·Sandipan DasguptaBhaskar Mazumder
Feb 8, 2018·Colloids and Surfaces. B, Biointerfaces·Lorena TavanoRita Muzzalupo
Oct 21, 2018·Pharmaceutics·Vijay MishraJessica M Rosenholm
Dec 12, 2018·Colloids and Surfaces. B, Biointerfaces·Seyyed Sohrab RostamkalaeiAli Nokhodchi
Dec 29, 2020·Asian Journal of Pharmaceutical Sciences·Jigar ShahMohamed Aly Morsy
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ameeduzzafar ZafarMohamed F Ibrahim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.