Apr 5, 2008

Innovative treatment strategies for patients with rheumatoid arthritis

Current Opinion in Rheumatology
Sjoerd M van der KooijFerdinand C Breedveld

Abstract

The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis. As early treatment is crucial to achieve optimal results, identifying patients with rheumatoid arthritis early is imperative to achieve clinical remission. Patients with early arthritis who will progress to rheumatoid arthritis can be identified, and treating these patients can postpone the diagnosis of rheumatoid arthritis and retard the progression of structural damage. The best way to achieve remission is by adjusting treatments at regular intervals using predetermined response criteria. Specific treatments to rapidly induce remission include disease modifying antirheumatic drugs combinations, especially combined with glucocorticoids or tumor necrosis factor antagonists. The prediction of joint damage progression, or the response to specific drugs is not yet accurately possible. The early institution of tumor necrosis factor antagonists followed by discontinuation leads to sustained clinical benefit. Early treatment of patients with rheumatoid arthritis with strategies aiming at remission results in the best outcomes. Until the prediction of a severe disease course and treatment re...Continue Reading

  • References50
  • Citations16

References

  • References50
  • Citations16

Citations

Mentioned in this Paper

Antirheumatic Drugs, Disease-Modifying
Tumor Necrosis Factor-alpha
Glucocorticoid inhalants for obstructive airway disease
Glucocorticoids, Systemic
Polychemotherapy
Rheumatoid Arthritis
Cancer Remission
Remission Induction
TNF gene
Tumor Necrosis Factors

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