Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms

Chemical Research in Toxicology
T SakuraiC Matsubara

Abstract

We demonstrate in this study the cytotoxic effects of inorganic arsenicals, arsenite and arsenate, and organic arsenic compounds, monomethylarsonic acid (MAA), dimethylarsinic acid (DMAA), and trimethylarsine oxide (TMAO), which are metabolites of inorganic arsenicals in human bodies, using murine macrophages in vitro. Inorganic arsenicals, both arsenite and arsenate, are strongly toxic to macrophages, and the concentration that decreased the number of surviving cells to 50% of that in untreated controls (IC50) was 5 or 500 microM, respectively. These inorganic arsenicals mainly caused necrotic cell death with partially apoptotic cell death; about 80% of dead cells were necrotic, and 20% were apoptotic. The inorganic arsenicals also induced marked release of an inflammatory cytokine, tumor necrosis factor alpha (TNF alpha), at cytotoxic doses. This strong cytotoxicity of an inorganic arsenical, arsenite, might be mediated via active oxygen and protease activation because it was inhibited by the addition of some antioxidant reagents, such as superoxide dismutase (SOD), catalase, and GSH, or by a peptide inhibitor of interleukin-1 beta-converting enzyme (ICE). It is likely that these immunotoxic effects of inorganic arsenicals ma...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Mar 1, 1992·American Journal of Epidemiology·M N BatesC Hopenhayn-Rich
Jun 1, 1982·British Journal of Cancer·J CuzickD A Price Evans
Oct 1, 1983·Environmental Research·M Vahter, J Envall
Jun 1, 1984·Chemico-biological Interactions·E Marafante, M Vahter
Jan 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Sep 1, 1993·Chemico-biological Interactions·D J Thompson
May 1, 1997·Archives of Environmental Contamination and Toxicology·K YoshidaG Endo

❮ Previous
Next ❯

Citations

Feb 5, 2009·Environmental Geochemistry and Health·Mohammad Mahmudur RahmanRavi Naidu
Feb 16, 2006·Journal of Biomedical Science·Wen-Jen LuJin-Ding Huang
Sep 1, 2007·Hepatology International·Shiv Kumar SarinUNKNOWN Members of the APASL Working Party on Portal Hypertension
Mar 5, 2004·International Immunopharmacology·Teruaki SakuraiKitao Fujiwara
Mar 5, 2004·Toxicology and Applied Pharmacology·Teruaki SakuraiKitao Fujiwara
Apr 23, 2003·Journal of Inorganic Biochemistry·Nishtar Nishad FathimaBalachandran Unni Nair
Nov 23, 2000·Toxicology Letters·Y RuanR L Vorce
Aug 23, 2001·Mutation Research·F I AbdullaevJ J Espinosa-Aguirre
May 19, 2001·International Immunopharmacology·M T Harrison, K L McCoy
Feb 19, 2005·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Maciej StepnikDobrosława Lewińska
Nov 26, 2009·Journal of the National Cancer Institute·Chikara KojimaMichael P Waalkes
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Chikara KojimaSeiichiro Himeno
Jun 12, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Halina MilnerowiczMagdalena Dul
May 16, 2006·International Journal of Environmental Research and Public Health·Laila N IslamAzizul I Kazi
Jan 13, 2012·Environmental Toxicology and Pharmacology·Wasif AhmadSouvendra Nath Sarkar
Mar 17, 2010·Toxicology and Applied Pharmacology·Ana L LunaEmma S Calderon-Aranda
Aug 25, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mónica A PalmieriBeatriz L Molinari
Jun 21, 2005·Toxicology and Applied Pharmacology·Teruaki SakuraiKitao Fujiwara
Sep 16, 2006·Toxicon : Official Journal of the International Society on Toxinology·Eiji OtaSeiichiro Himeno
Sep 3, 2014·Environmental and Molecular Mutagenesis·Hsin-Ling YangYou-Cheng Hseu
Feb 8, 2006·International Immunopharmacology·Teruaki SakuraiKitao Fujiwara
Oct 17, 2001·Toxicology and Applied Pharmacology·D J ThomasS Lin
Aug 24, 2005·Immunopharmacology and Immunotoxicology·Joanna ArkuszMaciej Stepnik
Sep 30, 2004·International Immunopharmacology·Teruaki SakuraiKitao Fujiwara
Feb 16, 2005·Toxicology and Applied Pharmacology·Teruaki SakuraiKitao Fujiwara
Jan 5, 2000·Oncogene·A C PorterR R Vaillancourt
Oct 24, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Laila N IslamM Shamim H Zahid
Jan 27, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chikara KojimaTeruaki Sakurai
Dec 21, 2011·Journal of Immunotoxicology·Saleem KhanJ K Malik
Jul 9, 2004·Critical Reviews in Toxicology·E DoppA V Hirner
May 9, 2003·Cancer Chemotherapy and Pharmacology·Hatice DuzkaleSrdan Verstovsek
Sep 8, 2010·Journal of Inorganic Biochemistry·Lingzhi Bao, Honglian Shi
Nov 3, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ravi ShuklaMurali Sastry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis